Faculty of Health Sciences, University of Buea, Buea, Cameroon.
Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Pan Afr Med J. 2021 Apr 28;38:405. doi: 10.11604/pamj.2021.38.405.25614. eCollection 2021.
thyroid cancer (TC) is considered to have become the fastest growing cancer in terms of incidence worldwide. Despite literature reporting a prevalence of 5-10% in clinically identified thyroid nodules, Cameroon still has limited data on the profile of TCs in patients with Nodular Goitres (NGs). The Objective were to describe the epidemiological, diagnostic and therapeutic profiles of TCs in patients with nodular goitres at the Douala General Hospital (DGH).
this was a retrospective cross-sectional analysis of patient records with diagnoses of NGs, over 11 years (2006 to 2016) at the DGH.
overall, 187 patients (mean age= 46.8±13.9 years, men=27 (14.4%)) were included; 43 (23%) cancers were identified. The most common histological type was papillary cancer (50%). Nodule size of >4cm and hypoechogenicity were independently associated with malignancy. Most patients presented with TNM stage II (47.4%) and well-differentiated cancers were considered to be predominantly at low-risk according to MACIS (55%) and AMES (74%) scores. Surgery was offered to 95.3% of patients.
TCs are frequent in patients with NGs with papillary cancer dominating. A high index of suspicion should be held if a nodule is >4cm and/or is hypoechogenic. Prognostic studies are needed to describe the outcome of TCs in our setting.
甲状腺癌（TC）被认为是全球发病率增长最快的癌症。尽管文献报道临床上发现的甲状腺结节中 TC 的患病率为 5-10%，但喀麦隆在结节性甲状腺肿（NG）患者中 TC 特征的数据仍然有限。本研究旨在描述杜阿拉总医院（DGH） NG 患者 TC 的流行病学、诊断和治疗特征。
这是一项回顾性的横断面分析，对 2006 年至 2016 年间在 DGH 诊断为 NG 的患者的病历进行了研究。
共纳入 187 例患者（平均年龄 46.8±13.9 岁，男性 27 例[14.4%]）；43 例（23%）被诊断为癌症。最常见的组织学类型是乳头状癌（50%）。结节大小>4cm 和低回声与恶性肿瘤独立相关。大多数患者的 TNM 分期为 II 期（47.4%），根据 MACIS（55%）和 AMES（74%）评分，分化良好的癌症被认为主要为低危。95.3%的患者接受了手术治疗。
TC 在 NG 患者中较为常见，其中乳头状癌占主导地位。如果结节>4cm 且/或呈低回声，应高度怀疑为 TC。需要进行预后研究以描述我们环境中 TC 的结局。
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