Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, PR China.
Departments of Radiology, Obstetrics & Gynecology Hospital, Fudan University, Shanghai, PR China.
Acta Radiol. 2022 Oct;63(10):1415-1424. doi: 10.1177/02841851211035915. Epub 2021 Aug 12.
Differentiating adenosquamous carcinoma (ASC) and adenocarcinoma (AC) from squamous cell carcinoma (SCC) precisely is crucial for treatment strategy and prognosis prediction in patients with cervical cancer (CC).
To differentiate ASC and AC from SCC in patients with CC using the apparent diffusion coefficient (ADC) histogram analysis.
A total of 118 patients with histologically diagnosed ASC, AC, and SCC were included. The ADC histogram parameters were extracted from ADC maps. Receiver operating characteristic analysis was performed to evaluate the diagnostic performance of each ADC histogram parameter in differentiating the subtypes of CC. The predictors for histologic subtypes were further selected using univariate and multivariate logistic regression analyses.
The ADC, ADC, ADC, ADC, ADC, ADC, ADC, and ADC of the ASC were significantly lower than those of the AC; and ADC and ADC of the ASC were lower than those of the SCC. The ADC, ADC, ADC, ADC, ADC, ADC, ADC, and ADC of AC were significantly higher than those of the SCC. The ADC and ADC + diameter yielded the AUCs of 0.753 and 0.778 in differentiating ASC from AC. The ADC and ADC + diameter yielded the AUCs of 0.807 and 0.838 in differentiating AC from SCC. The ADC yielded the AUC of 0.713 in differentiating ASC from SCC.
The ADC and ADC + diameter, ADC, and ADC + diameter performed well in differentiating ASC from AC and AC from SCC, respectively. However, ADC exhibited a limited ability in differentiating ASC from SCC.
准确地区分宫颈癌（CC）中的腺鳞癌（ASC）和腺癌（AC）与鳞状细胞癌（SCC）对于治疗策略和预后预测至关重要。
使用表观扩散系数（ADC）直方图分析区分 CC 患者中的 ASC 和 AC 与 SCC。
共纳入 118 例经组织学诊断为 ASC、AC 和 SCC 的患者。从 ADC 图中提取 ADC 直方图参数。通过接收者操作特征分析评估每个 ADC 直方图参数在区分 CC 亚型方面的诊断性能。使用单变量和多变量逻辑回归分析进一步选择组织学亚型的预测因子。
ASC 的 ADC、ADC、ADC、ADC、ADC、ADC、ADC 和 ADC 值明显低于 AC；而 ASC 的 ADC 和 ADC 值低于 SCC。AC 的 ADC、ADC、ADC、ADC、ADC、ADC、ADC 和 ADC 值明显高于 SCC。ADC 和 ADC+diameter 在区分 ASC 与 AC 方面的 AUC 分别为 0.753 和 0.778。ADC 和 ADC+diameter 在区分 AC 与 SCC 方面的 AUC 分别为 0.807 和 0.838。ADC 在区分 ASC 与 SCC 方面的 AUC 为 0.713。
ADC 和 ADC+diameter、ADC 和 ADC+diameter 在区分 ASC 与 AC 和 AC 与 SCC 方面表现良好，而 ADC 在区分 ASC 与 SCC 方面能力有限。
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