lncRNA 在卵巢功能及相关疾病中的作用及其作为 ceRNA 的研究进展。
Research progress in lncRNA and its action as ceRNA in ovarian function as well as the relevant diseases.
机构信息
Department of Gynecology of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023.
Department of Gynaecology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Jul 28;46(7):745-752. doi: 10.11817/j.issn.1672-7347.2021.200622.
Long chain non-encoding RNA (lncRNA) can affect gene expression through transcription, post transcriptional regulation and epigenetic modification, and it is involved in regulating ovarian physiological function. LncRNA, as a competitive endogenous RNA, can affect the expression of target gene mRNA by competitively binding microRNA (miRNA), which are called lncRNA/miRNA/mRNA regulatory network. It plays an important role in the regulation of ovarian physiological function and the occurrence and development of ovarian reproductive disorders, expecting to become a new target and diagnostic index for the treatment of reproductive disorders.
长链非编码 RNA（lncRNA）可以通过转录、转录后调控和表观遗传修饰来影响基因表达，并且参与调节卵巢的生理功能。lncRNA 作为一种竞争性内源性 RNA，可以通过竞争性结合 microRNA（miRNA）来影响靶基因 mRNA 的表达，这种现象被称为 lncRNA/miRNA/mRNA 调控网络。它在卵巢生理功能的调节以及卵巢生殖障碍的发生和发展中起着重要作用，有望成为生殖障碍治疗的新靶点和诊断指标。
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