腹壁脂肪抽吸术与瘦素激素
Lipoabdominoplasty and the leptin hormone.
作者信息
Ghafoor Leila, Entezari Vahid, Fallah Atefe, Hajian Abbas
机构信息
Department of General Surgery, Kashan University of Medical Sciences, Kashan, Iran.
Kashan University of Medical Sciences, Kashan, Iran.
出版信息
Ann Med Surg (Lond). 2021 Jul 28;68:102633. doi: 10.1016/j.amsu.2021.102633. eCollection 2021 Aug.
BACKGROUND
Obesity contributes to a chronic disease with lethal complications. Leptin as an adiponectin interacts with fat metabolism. Surgical extra fat resection is an interventional approach to control obesity. We aimed to evaluate how body contouring surgery would influence on leptin plasma level.
METHODS
Females candidate for body contouring surgery were allocated in to two groups included abdominal wall liposuction alone and in combination with abdominoplasty from 2018 to 2020. Demographic data was registered. Serum plasma level of leptin with the ELISA method was measured on the day before the operation and also after 3, 6, and 12 months after surgery with 8 h fasting prior to blood sampling. Finally the amounts of resected fat, type of surgical approach, and plasma level of leptin were analyzed.
RESULTS
Total 124 females with mean age of 37 ± 10.1 years underwent abdominal wall liposuction (58%) and liposuction + abdominoplasty (42%) respectively. Mean weight and BMI significantly decreased postoperatively for both groups (p < 0.01). Although in both groups leptin concentration was higher in all triple blood sampling following operation in compared to preoperative measurement, changes were not significantly considerable (p = 0.6). Coefficient of correlation between amounts of resected fat and plasma level of leptin was directly positive and calculated 0.4 (p = 0.03).
CONCLUSION
Leptin interacts independently from abdominal wall contouring surgery. However it could be a marker for amounts of resected fat after operation.
背景
肥胖会引发伴有致命并发症的慢性疾病。瘦素作为一种脂联素，与脂肪代谢相互作用。手术切除多余脂肪是控制肥胖的一种干预方法。我们旨在评估身体塑形手术如何影响瘦素血浆水平。
方法
2018年至2020年，将符合身体塑形手术条件的女性分为两组，分别为单纯腹壁吸脂组和腹壁吸脂联合腹壁成形术组。记录人口统计学数据。采用酶联免疫吸附测定法（ELISA法）在手术前一天以及术后3个月、6个月和12个月且采血前禁食8小时时测量血清瘦素水平。最后分析切除脂肪量、手术方式及瘦素血浆水平。
结果
共有124名平均年龄为37±10.1岁的女性分别接受了腹壁吸脂术（58%）和吸脂联合腹壁成形术（42%）。两组术后平均体重和体重指数均显著下降（p<0.01）。虽然两组术后三次采血时的瘦素浓度均高于术前测量值，但变化并不显著（p = 0.6）。切除脂肪量与瘦素血浆水平之间的相关系数为直接正相关，计算值为0.4（p = 0.03）。
结论
瘦素与腹壁塑形手术无关。然而，它可能是术后切除脂肪量的一个指标。
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