镉与心血管疾病：病理生理学、流行病学、治疗学和预测价值概述。

Cadmium and cardiovascular disease: An overview of pathophysiology, epidemiology, therapy, and predictive value.

机构信息

Department of Cardiology, Huashan Hospital of Fudan University, Shanghai, China; Shanghai Medical College, Fudan University, Shanghai, China.

Shanghai Medical College, Fudan University, Shanghai, China; Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, Shanghai, China.

出版信息

Rev Port Cardiol (Engl Ed). 2021 Aug;40(8):611-617. doi: 10.1016/j.repce.2021.07.031.

DOI:10.1016/j.repce.2021.07.031

PMID:34392906

Abstract

Cadmium is a widely distributed toxic heavy metal that has been associated with many diseases including chronic renal dysfunction, osteomalacia, acute heart failure, secondary hypertension, and atherosclerosis. Although several studies have suggested that cadmium may affect multiple systems by inducing lipid per oxidation in cells and disturbing the antioxidant system, the mechanism by which cadmium affects the cardiovascular system remains unclear. Recent studies on heart failure and acute myocardial infarction have shown that cadmium has good predictive ability for mortality in patients with cardiovascular disease. In this study, we briefly review the role of cadmium in cardiovascular disease, which may prompt further studies to investigate the potential association between cadmium and mortality in patients with cardiovascular disease.

摘要

镉是一种广泛分布的有毒重金属，与许多疾病有关，包括慢性肾功能障碍、佝偻病、急性心力衰竭、继发性高血压和动脉粥样硬化。虽然有几项研究表明，镉可能通过诱导细胞内脂质过氧化和扰乱抗氧化系统来影响多个系统，但镉影响心血管系统的机制尚不清楚。最近关于心力衰竭和急性心肌梗死的研究表明，镉对心血管疾病患者的死亡率具有良好的预测能力。在本研究中，我们简要回顾了镉在心血管疾病中的作用，这可能促使进一步研究探讨镉与心血管疾病患者死亡率之间的潜在关联。