Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario L9G 4X5, Canada; Department of Radiology, McMaster University, 1200 Main Street West, Hamilton, Ontario L9G 4X5, Canada.
Department of Radiology, McMaster University, 1200 Main Street West, Hamilton, Ontario L9G 4X5, Canada.
Radiol Clin North Am. 2021 Sep;59(5):693-703. doi: 10.1016/j.rcl.2021.05.002.
Precision medicine integrates molecular pathobiology, genetic make-up, and clinical manifestations of disease in order to classify patients into subgroups for the purposes of predicting treatment response and suggesting outcome. By identifying those patients who are most likely to benefit from a given therapy, interventions can be tailored to avoid the expense and toxicity of futile treatment. Ultimately, the goal is to offer the right treatment, to the right patient, at the right time. Lung cancer is a heterogeneous disease both functionally and morphologically. Further, over time, clonal proliferations of cells may evolve, becoming resistant to specific therapies. PET is a sensitive imaging technique with an important role in the precision medicine algorithm of lung cancer patients. It provides anatomo-functional insight during diagnosis, staging, and restaging of the disease. It is a prognostic biomarker in lung cancer patients that characterizes tumoral heterogeneity, helps predict early response to therapy, and may direct the selection of appropriate treatment.
精准医学综合了分子病理生物学、遗传构成和疾病的临床表现，以便将患者分为亚组，目的是预测治疗反应并提示预后。通过识别那些最有可能从特定治疗中获益的患者，可以针对那些无效治疗的费用和毒性进行干预，从而避免这些治疗。最终的目标是在正确的时间为正确的患者提供正确的治疗。肺癌在功能和形态上都是一种异质性疾病。此外，随着时间的推移，细胞的克隆增殖可能会发生演变，从而对特定的治疗产生耐药性。PET 是一种敏感的成像技术，在肺癌患者的精准医学算法中具有重要作用。它在疾病的诊断、分期和再分期过程中提供解剖-功能方面的信息。它是肺癌患者的预后生物标志物，可以描述肿瘤异质性，有助于预测早期治疗反应，并可能指导选择合适的治疗方法。
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