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在心血管疾病风险增加的患者中,医生配药作为临床和过程测量的一个决定因素:瑞士全科医疗的一项横断面研究。

Physician-dispensing as a determinant of clinical and process measurements in patients at increased cardiovascular risk: A cross-sectional study in Swiss general practice.

作者信息

Rachamin Yael, Meier Rahel, Valeri Fabio, Rosemann Thomas, Muheim Leander

机构信息

Institute of Primary Care, University of Zurich and University Hospital Zurich, Pestalozzistrasse 24, 8091 Zurich, Switzerland.

Institute of Primary Care, University of Zurich and University Hospital Zurich, Pestalozzistrasse 24, 8091 Zurich, Switzerland.

出版信息

Health Policy. 2021 Oct;125(10):1305-1310. doi: 10.1016/j.healthpol.2021.07.014. Epub 2021 Aug 4.

Abstract

AIMS

In some healthcare systems, physicians are allowed to dispense drugs; in others, drug-dispensing is restricted to pharmacists. Whether physician-dispensing affects patient health is unknown. Thus, we aimed to investigate associations between physician-dispensing and clinical and process measurements in patients with selected long-term conditions indicating increased cardiovascular risk.

METHODS

Retrospective cross-sectional study in 2018 based on data from electronic medical records of 22405 patients (73.6% physician-dispensing) in Switzerland with medications for diabetes mellitus, arterial hypertension, or lipid-related disorders. We used multilevel regression models to determine the associations between physician-dispensing and clinical measurements (glycated hemoglobin [HbA1c], systolic blood pressure [sBP], low-density lipoprotein cholesterol [LDL-C]) or process measurements (number of annual clinical measurements, consultations, and drug prescriptions).

RESULTS

Median (interquartile range) HbA1c value was 6.8% (6.3-7.5) both for the physician-dispensing and pharmacist-dispensing group, sBP was 137 (126-150) and 136 mmHg (126-149), and LDL-C was 2.3 (1.8-3.0) and 2.5 mmol/L (1.9-3.2). After adjustments, the physician-dispensing group had 4% lower LDL-C levels (p = 0.041), 12% more frequent HbA1c measurements (p = 0001), 16% higher annual consultation rates (p < 0.05 for all conditions), and equal number of different drugs, compared to the pharmacist-dispensing group.

CONCLUSIONS

We found no relevant differences in selected clinical measurements between physician- and pharmacist-dispensing, and mixed results in process measurements. Our results do not indicate that one drug-dispensing channel is superior to the other.

摘要

目的

在一些医疗体系中,医生被允许配药;而在其他体系中,配药则仅限于药剂师。医生配药是否会影响患者健康尚不清楚。因此,我们旨在调查医生配药与患有特定长期疾病且心血管风险增加的患者的临床及过程指标之间的关联。

方法

基于2018年瑞士22405名患者(73.6%由医生配药)电子病历数据进行回顾性横断面研究,这些患者患有糖尿病、动脉高血压或血脂相关疾病。我们使用多水平回归模型来确定医生配药与临床指标(糖化血红蛋白[HbA1c]、收缩压[sBP]、低密度脂蛋白胆固醇[LDL-C])或过程指标(每年临床检查、会诊及药物处方的数量)之间的关联。

结果

医生配药组和药剂师配药组的HbA1c中位数(四分位间距)均为6.8%(6.3 - 7.5),sBP分别为137(126 - 150)和136 mmHg(126 - 149),LDL-C分别为2.3(1.8 - 3.0)和2.5 mmol/L(1.9 - 3.2)。调整后,与药剂师配药组相比,医生配药组的LDL-C水平低4%(p = 0.041),HbA1c测量频率高12%(p = 0.001),年会诊率高16%(所有疾病情况p < 0.05),且不同药物数量相同。

结论

我们发现医生配药和药剂师配药在所选临床指标上无相关差异,在过程指标上结果不一。我们的结果并未表明一种配药渠道优于另一种。

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