镰状细胞病患者与不伴有α-地中海贫血的镰状细胞病患者之间的氧梯度 ektacytometry 参数比较。
Comparisons of oxygen gradient ektacytometry parameters between sickle cell patients with or without α-thalassaemia.
机构信息
Team 'Vascular Biology and Red Blood Cell', Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Université Claude Bernard Lyon 1, Université de Lyon, Villeurbanne, France.
Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France.
出版信息
Br J Haematol. 2021 Nov;195(4):629-633. doi: 10.1111/bjh.17777. Epub 2021 Aug 15.
The present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO ) was greater and the pO at which RBC started to sickle was lower in the two α-genes group compared to the other groups. Our present study showed an effect of α-thalassaemia on oxygen gradient ektacytometry in SCA.
本研究旨在检验α-地中海贫血对镰状细胞贫血（SCA）中氧梯度锥虫检测的影响。将 SCA 患者分为三组进行比较：（i）无α-地中海贫血（四个α-基因，n=62）；（ii）静止型α-地中海贫血（三个α-基因，n=35）；（iii）纯合子α-地中海贫血（两个α-基因，n=12）。三组患者在常氧条件下的红细胞（RBC）变形能力并无差异。与其他两组相比，在低氧分压（pO ）下 RBC 达到的最低变形能力更大，且开始镰变的 pO 更低。本研究表明α-地中海贫血对 SCA 中氧梯度锥虫检测有影响。
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