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唾液肽检测用于咽喉反流和胃食管反流病：系统评价和荟萃分析。

Salivary peptest for laryngopharyngeal reflux and gastroesophageal reflux disease: A systemic review and meta-analysis.

机构信息

Department of Gastroenterology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.

Department of Cardiovascular diseases, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China.

出版信息

Medicine (Baltimore). 2021 Aug 13;100(32):e26756. doi: 10.1097/MD.0000000000026756.

DOI:10.1097/MD.0000000000026756

PMID:34397878

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8360476/

Abstract

BACKGROUND

A rapid lateral flow test (Peptest) to detect pepsin in saliva/sputum has been considered as a valuable method for diagnosing laryngopharyngeal reflux (LPR) and gastroesophageal reflux disease (GERD). The aim of this meta-analysis is to analyze the utility of Peptest for diagnosis of LPR and GERD.

METHODS

PubMed, EMBASE, and the Cochran Library (from January 1980 to 26 January 2020) were searched for pepsin in saliva for LPR/GERD diagnosis. Sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve data were summarized to examine the accuracy.

RESULTS

A total of 16 articles that included 2401 patients and 897 controls were analyzed. The pooled sensitivity and specificity for the diagnosis of GERD/LPR with Peptest were 62% (95% confidence interval [CI] 49%-73%) and 74% (95% CI 50%-90%), respectively. The summarized diagnostic odds ratio and area under the curve were 5.0 (95% CI 2-19) and 0.70 (95% CI 0.66-0.74), respectively.

CONCLUSION

Peptest shows moderate diagnostic value for LPR and GERD. More studies with standard protocols should be done to verify its usefulness.

摘要

背景

快速侧向流动试验（Peptest）检测唾液/痰中的胃蛋白酶已被认为是诊断喉咽反流（LPR）和胃食管反流病（GERD）的有价值方法。本荟萃分析的目的是分析 Peptest 对 LPR 和 GERD 的诊断价值。

方法

检索 PubMed、EMBASE 和 Cochrane 图书馆（1980 年 1 月至 2020 年 1 月 26 日）中用于 LPR/GERD 诊断的唾液胃蛋白酶检测。汇总敏感性、特异性、阳性似然比、阴性似然比、诊断比值比和曲线下面积数据以评估准确性。

结果

共分析了 16 项纳入 2401 例患者和 897 例对照的研究。Peptest 诊断 GERD/LPR 的汇总敏感性和特异性分别为 62%（95%置信区间 49%-73%）和 74%（95%置信区间 50%-90%）。汇总的诊断比值比和曲线下面积分别为 5.0（95%置信区间 2-19）和 0.70（95%置信区间 0.66-0.74）。