缓激肽对不同钠摄入量的自发性高血压大鼠血压调节的影响。

Influence of bradykinin on blood pressure regulation of spontaneously hypertensive rats maintained on different sodium intakes.

Waeber B, Aubert J F, Nussberger J, Vavrek R, Stewart J M, Brunner H R

Division of Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Clin Exp Pharmacol Physiol. 1987 Aug;14(8):659-64. doi: 10.1111/j.1440-1681.1987.tb01887.x.

Abstract

The role of circulating bradykinin in blood pressure regulation was studied in conscious spontaneously hypertensive rats utilizing the competitive antagonist of bradykinin B4162. 2. This antagonist was administered at a bolus dose (400 micrograms i.v.) known to block the hypotensive effect of exogenous bradykinin for at least 2 min. The rats were maintained for 10 days either on a low or a high sodium intake. 3. The antagonist of bradykinin significantly increased blood pressure only in salt-depleted rats. In other rats kept on a low or a high sodium intake, dose-response curves to exogenous bradykinin were established. Dietary sodium had no influence on the blood pressure-lowering effect of bradykinin. 4. These data therefore suggest that circulating bradykinin may be involved in the blood pressure control of spontaneously hypertensive rats when the renin-angiotensin system is stimulated by salt depletion.

摘要

利用缓激肽竞争性拮抗剂B4162，在清醒的自发性高血压大鼠中研究了循环缓激肽在血压调节中的作用。2. 以已知能阻断外源性缓激肽降压作用至少2分钟的大剂量（静脉注射400微克）给予该拮抗剂。大鼠维持10天低钠或高钠摄入。3. 缓激肽拮抗剂仅在缺盐大鼠中显著升高血压。在其他维持低钠或高钠摄入的大鼠中，建立了对外源性缓激肽的剂量-反应曲线。饮食钠对缓激肽的降压作用无影响。4. 因此，这些数据表明，当肾素-血管紧张素系统因缺盐而被激活时，循环缓激肽可能参与自发性高血压大鼠的血压控制。