基于 Heyns 重排的一锅串联反应制备和应用 α-亚氨基酮。
Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement.
机构信息
College of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, P.R. China.
Natural Products Research Center Chengdu Institution of Biology Chinese Academy of Science, Chengdu, Sichuan 610041, P.R. China.
出版信息
Org Lett. 2021 Sep 3;23(17):6819-6824. doi: 10.1021/acs.orglett.1c02390. Epub 2021 Aug 18.
α-Imino ketone is a useful building block for the preparation of α-amino ketones and α-amino alcohols. However, its preparation has been seldomly seen. Herein, a metal-free and operationally simple strategy has been developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.
α-亚氨基酮是制备α-氨基酮和α-氨基醇的有用砌块。然而，其制备方法很少见。本文开发了一种无金属且操作简单的策略，以高区域选择性生成α-亚氨基酮。同时，该方法通过一锅法的级联反应，可以高区域选择性和非对映选择性地制备各种 N,O-缩酮。
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