与镰状细胞肾病相关的预测因素：系统评价。
Predictors associated with sickle cell nephropathy: a systematic review.
机构信息
Pontifícia Universidade Católica de Goiás - Goiânia (GO), Brazil.
出版信息
Rev Assoc Med Bras (1992). 2021 Feb;67(2):313-317. doi: 10.1590/1806-9282.67.02.20200676.
INTRODUCTION
Sickle cell anemia affects more than 30 million people worldwide. Chronic kidney disease develops in 40% of individuals. The death rate of patients with sickle nephropathy is still high, with little known predictors related to its development. To answer the question "What predictors are associated with the onset of chronic kidney disease in patients with sickle cell anemia?", this article seeks to contribute to a better understanding of sickle nephropathy, making possible a new look at the sickle cell anemia and its kidney complications.
METHODS
A systematic review was developed, using the PRISMA recommendation, for cohort studies on predictors related to the outcome of sickle nephropathy in patients with sickle cell anemia.
RESULTS
Initially 321 studies were identified in Pubmed, of which six were selected to compose this systematic review. Lower hemoglobin levels, increased ages and albuminuria were the most pointed predictors associated with chronic kidney disease.
CONCLUSION
The main predictors associated with the development of chronic kidney disease in individuals with sickle cell anemia were lower hemoglobin levels, increased ages, and albuminuria. New studies evaluating predictors for the development of chronic kidney disease in sickle cell anemia are needed to better understand its installation and prevent its progression.
简介
镰状细胞贫血影响全球超过 3000 万人。40%的个体发展为慢性肾脏病。镰状细胞肾病患者的死亡率仍然很高，其发展相关的预测因素知之甚少。为了回答“哪些预测因素与镰状细胞贫血患者慢性肾脏病的发生有关？”这一问题，本文旨在深入了解镰状细胞肾病，从而可能重新审视镰状细胞贫血及其肾脏并发症。
方法
采用 PRISMA 建议，对与镰状细胞贫血患者镰状肾病结局相关的预测因素进行了系统评价。
结果
最初在 Pubmed 中确定了 321 项研究，其中 6 项被选入本系统评价。较低的血红蛋白水平、年龄增长和蛋白尿是与慢性肾脏病最相关的预测因素。
结论
与镰状细胞贫血患者慢性肾脏病发展相关的主要预测因素是血红蛋白水平较低、年龄增长和蛋白尿。需要新的研究来评估镰状细胞贫血慢性肾脏病发展的预测因素，以更好地了解其发病机制并预防其进展。
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