去神经支配后，大鼠垂体中间叶中阿片促黑激素皮质素原的生物合成增加。
Biosynthesis of pro-opiomelanocortin is increased in the rat intermediate pituitary following denervation.
作者信息
Seger M A, Kiss J Z, van Tol H H, Burbach J P
机构信息
Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, The Netherlands.
出版信息
Neurosci Lett. 1987 Dec 16;83(1-2):149-55. doi: 10.1016/0304-3940(87)90232-1.
In order to study the effect of pituitary intermediate lobe denervation on pro-opiomelanocortin (POMC) biosynthesis and processing, radioactive amino acids were incorporated in vitro into whole neurointermediate lobe (NIL) explants obtained from hypothalamic lesioned rats and control animals. The lesion in the basal hypothalamus removed the neural input to the intermediate pituitary and cut the neurohypophyseal neurons. One week after the lesion, approximately a 3-fold increase in the rate of synthesis of POMC peptides was found in the NIL. The content of POMC peptides was decreased. The results imply that denervation increases the rate of POMC synthesis and release, without altering the pattern of proteolytic processing.
为了研究垂体中间叶去神经支配对阿黑皮素原（POMC）生物合成及加工的影响，将放射性氨基酸在体外掺入从下丘脑损伤大鼠和对照动物获取的整个神经中间叶（NIL）外植体中。下丘脑底部的损伤消除了对垂体中间叶的神经输入并切断了神经垂体神经元。损伤后一周，在NIL中发现POMC肽的合成速率增加了约3倍。POMC肽的含量降低。结果表明，去神经支配增加了POMC的合成和释放速率，而不改变蛋白水解加工模式。
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