膳食壳聚糖喂养时间对糖尿病大鼠模型糖脂代谢的影响。

Influence of Dietary Chitosan Feeding Duration on Glucose and Lipid Metabolism in a Diabetic Rat Model.

机构信息

Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.

出版信息

Molecules. 2021 Aug 19;26(16):5033. doi: 10.3390/molecules26165033.

DOI:10.3390/molecules26165033

PMID:34443619

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8400972/

Abstract

This study was designed to investigate the influence of dietary chitosan feeding-duration on glucose and lipid metabolism in diabetic rats induced by streptozotocin and nicotinamide [a non-insulin-dependent diabetes mellitus (NIDDM) model]. Male Sprague-Dawley rats were used as experimental animals and divided into short-term (6 weeks) and long-term (11 weeks) feeding durations, and each duration contained five groups: (1) control, (2) control + 5% chitosan, (3) diabetes, (4) diabetes + 0.8 mg/kg rosiglitazone (a positive control), and (5) diabetes + 5% chitosan. Whether the chitosan feeding was for 6 or 11 weeks, the chitosan supplementation decreased blood glucose and lipids levels and liver lipid accumulation. However, chitosan supplementation decreased plasma tumor necrosis factor (TNF)-α, insulin levels, alanine aminotransferase (ALT) activity, insulin resistance (HOMA-IR), and adipose tissue lipoprotein lipase activity. Meanwhile, it increased plasma high-density lipoproteins (HDL)-cholesterol level, plasma angiopoietin-like-4 protein expression, and plasma triglyceride levels (at 11-week feeding duration only). Taken together, 11-week (long-term) chitosan feeding may help to ameliorate the glucose and lipid metabolism in a NIDDM diabetic rat model.

摘要

本研究旨在探讨饲粮壳聚糖喂养时间长短对链脲佐菌素和烟酰胺诱导的糖尿病大鼠（非胰岛素依赖型糖尿病[NIDDM]模型）葡萄糖和脂代谢的影响。雄性 Sprague-Dawley 大鼠作为实验动物，分为短期（6 周）和长期（11 周）两个喂养时间，每个时间又分为 5 组：（1）对照组，（2）对照组+5%壳聚糖，（3）糖尿病组，（4）糖尿病组+0.8mg/kg 罗格列酮（阳性对照组），（5）糖尿病组+5%壳聚糖。无论壳聚糖喂养 6 周还是 11 周，壳聚糖补充均降低了血糖和血脂水平，减少了肝脏脂质堆积。然而，壳聚糖补充降低了血浆肿瘤坏死因子（TNF）-α、胰岛素水平、丙氨酸氨基转移酶（ALT）活性、胰岛素抵抗（HOMA-IR）和脂肪组织脂蛋白脂肪酶活性。同时，它增加了血浆高密度脂蛋白（HDL）-胆固醇水平、血浆血管生成素样蛋白 4 蛋白表达和血浆甘油三酯水平（仅在 11 周喂养时间）。综上所述，11 周（长期）壳聚糖喂养可能有助于改善 NIDDM 糖尿病大鼠模型的葡萄糖和脂代谢。