C Giurgescu, D P Misra, J C Slaughter-Acey, S L Gillespie, A L Nowak, E Dove-Medows, C G Engeland, S N Zenk, T A Lydic, S Sealy-Jefferson, J Ford, S Drury, P Stemmer
University of Central Florida, Orlando, FL, USA.
Michigan State University, East Lansing, MI, USA.
West J Nurs Res. 2022 Jan;44(1):101-110. doi: 10.1177/01939459211041165. Epub 2021 Aug 28.
African American women are more likely to experience preterm birth (<37 completed weeks gestation) compared with White women. African American women are also more likely to live in neighborhoods characterized as disadvantaged (i.e., exhibiting higher rates of vacant housing, poorer property conditions, and more litter and crime) and to experience racial discrimination compared with White women. These chronic stressors have been related to preterm birth (PTB) among African American women. This review focuses on potential stress-related pathways by which neighborhood disadvantage and racial discrimination increase the risk for PTB among African American women. Specifically, we propose cortisol, systemic inflammation, proteome and lipidome profiles, and telomere shortening as potential mediators linking these social determinants of health with PTB among African American women. Examination of these factors and the signaling pathways they contribute to will increase our knowledge of the effects of social determinants of health on PTB for African American women.
与白人女性相比，非裔美国女性更有可能经历早产（妊娠不足37周）。与白人女性相比，非裔美国女性也更有可能居住在被视为弱势的社区（即空置住房率更高、房产状况更差、垃圾和犯罪更多），并遭受种族歧视。这些慢性应激源与非裔美国女性的早产有关。本综述重点关注邻里弱势和种族歧视增加非裔美国女性早产风险的潜在应激相关途径。具体而言，我们提出皮质醇、全身炎症、蛋白质组和脂质组谱以及端粒缩短是将这些健康社会决定因素与非裔美国女性早产联系起来的潜在中介因素。对这些因素及其所促成的信号通路进行研究，将增加我们对健康社会决定因素对非裔美国女性早产影响的认识。
