白细胞介素-6基因-174G>C启动子多态性降低巴西人群患牙周炎的风险：一项荟萃分析。

Interleukin-6 gene -174G>C promoter polymorphism reduces the risk of periodontitis in Brazilian populations: A meta-analysis.

作者信息

Mehar Raju, Swarnakar Shashikant, Lakkakula Saikrishna, Verma Henu Kumar, Bhaskar L V K S

机构信息

Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India.

Department of Biochemistry, Late Atal Bihari Vajpayee Memorial Medical College Rajnandgaon (C.G.), India.

出版信息

J Oral Biosci. 2021 Dec;63(4):388-393. doi: 10.1016/j.job.2021.08.003. Epub 2021 Aug 31.

DOI:10.1016/j.job.2021.08.003

PMID:34478874

Abstract

INTRODUCTION

Periodontitis is a multifactorial host-mediated oral disease caused by microbes. Previous studies suggested that interleukin-6 (IL-6) gene promoter polymorphism (-174G > C) are associated with the risk of periodontitis, although the results were inconclusive. This study investigated the association between IL-6 -174G > C polymorphism and susceptibility to periodontitis.

METHOD

A comprehensive search was conducted in PubMed, EMBASE, Web of Science, and Google Scholar databases to retrieve relevant studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the association between 174G > C polymorphism and the risk of periodontitis. Cochrane Q and I statistics were used to measure heterogeneity between studies. Publication bias was estimated using Begg's funnel plots and Egger's test.

RESULTS

Our results showed significant differences in the allelic (C vs. G: OR = 0.82, CI = 0.65-1.03), recessive (CC vs. GC + GG: OR = 0.69, CI = 0.42-1.13), and dominant (GC + CC vs. GG: OR = 0.85, CI = 0.63-1.13) genetic models of the IL6 -174G > C polymorphism and risk of periodontitis. Further, subgroup analysis showed decreased susceptibility to periodontitis associated with IL6 -174 G > C in a Brazilian population (C vs. G: OR = 0.60, CI = 0.41-0.88; GC + CC vs. GG: OR = 0.57, CI = 0.42-0.78) but not in Asian or Caucasian populations.

CONCLUSION

The findings of this study revealed that the IL6 -174 "C" allele is protective against periodontitis in the Brazilian population.

摘要

引言

牙周炎是一种由微生物引起的多因素宿主介导的口腔疾病。先前的研究表明，白细胞介素-6（IL-6）基因启动子多态性（-174G>C）与牙周炎风险相关，尽管结果尚无定论。本研究调查了IL-6 -174G>C多态性与牙周炎易感性之间的关联。

方法

在PubMed、EMBASE、科学网和谷歌学术数据库中进行全面检索，以获取相关研究。计算合并比值比（OR）和95%置信区间（CI），以评估174G>C多态性与牙周炎风险之间关联的强度。采用Cochrane Q和I统计量来衡量研究之间的异质性。使用Begg漏斗图和Egger检验评估发表偏倚。

结果

我们的结果显示，IL6 -174G>C多态性的等位基因（C与G：OR = 0.82，CI = 0.65 - 1.03）、隐性（CC与GC + GG：OR = 0.69，CI = 0.42 - 1.13）和显性（GC + CC与GG：OR = 0.85，CI = 0.63 - 1.13）遗传模型与牙周炎风险存在显著差异。此外，亚组分析显示，巴西人群中IL6 -174 G>C与牙周炎易感性降低相关（C与G：OR = 0.60，CI = 0.41 - 0.88；GC + CC与GG：OR = 0.57，CI = 0.42 - 0.78），但在亚洲或白种人群中并非如此。