Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Biotechnology Research Institute, Bahir Dar University, Bahir Dar, Ethiopia.
Ethiop J Health Sci. 2021 May;31(3):653-662. doi: 10.4314/ejhs.v31i3.23.
Tuberculosis and human immunodeficiency virus (HIV) are among the major health problems in Ethiopia. This study assessed the proportion of tuberculosis lymphadenitis (TBLN), HIV infection and their co-infection among TBLN presumptive individuals at the selected hospitals in Northwest Ethiopia.
Institution based cross sectional study was carried out. Data on demographic and clinical variables were collected with standardized questionnaire. Microbiological culture was done on specimen obtained by fine needle aspirates. The HIV status was determined by rapid anti-HIV antibody test. Data was entered and scrutinized using SPSS version 20 statistical packages. A stepwise logistic regression model was used. The result was considered as statistically significant at P<0. 05.
A total of 381 lymphadenitis patients were included in the study. The overall prevalence of TBLN and HIV were at 250(65.6%) and 9(2.4%), respectively and their co-infection was at 6(2.4%). Based on the cytological examination, 301(79.0%) of them were diagnosed as TBLN. The age group, (P=0.01) and residency, (P=0.01) were found significantly associated with TBLN. Similarly, unsafe sex was also statistically significant for HIV infection (P=0.007).
Tuberculosis lymphadenitis is the leading cause of TB and lymphadenitis in the region. However, TBLN-HIV coinfection was promisingly low. High rate of discrepancy was noticed between cytological and culture results. Hence, the TBLN diagnostic criteria shall pursue revision.
结核病和人类免疫缺陷病毒（HIV）是埃塞俄比亚的主要健康问题之一。本研究评估了在埃塞俄比亚西北部选定医院的疑似结核病性淋巴结炎（TBLN）个体中结核病性淋巴结炎（TBLN）、HIV 感染及其合并感染的比例。
进行了基于机构的横断面研究。使用标准化问卷收集人口统计学和临床变量数据。通过细针抽吸获得的标本进行微生物培养。HIV 状态通过快速抗 HIV 抗体检测确定。数据使用 SPSS 版本 20 统计软件包进行输入和审查。使用逐步逻辑回归模型。P<0.05 被认为具有统计学意义。
共纳入 381 例淋巴结炎患者。TBLN 和 HIV 的总患病率分别为 250（65.6%）和 9（2.4%），合并感染率为 6（2.4%）。根据细胞学检查，301（79.0%）例被诊断为 TBLN。年龄组（P=0.01）和居住地（P=0.01）与 TBLN 显著相关。同样，不安全的性行为对 HIV 感染也具有统计学意义（P=0.007）。
结核病性淋巴结炎是该地区结核病和淋巴结炎的主要原因。然而，TBLN-HIV 合并感染的比例令人鼓舞地较低。细胞学和培养结果之间存在高比例的差异。因此，TBLN 诊断标准应进行修订。
