女性新生儿出生体重作为其一生中患乳腺癌的危险因素：一项双中心病例对照研究。
Neonatal Birth Weight of the Woman as a Risk Factor for Breast Cancer in her Life: a Case-Control Bicentric Study.
作者信息
Bothou Anastasia, Zervoudis Stefanos, Tsatsaris Georgios, Pappou Panagiota, Liadopoulou Maria, Iatrakis Georgios, Gerende Aggeliki, Chalkidou Anna, Nikolettos Nikolaos, Tsikouras Panagiotis
机构信息
Department of Midwifery, University of West Attica (UniWA), Athens, Greece.
Neonatal Department, "Alexandra" General Hospital, Athens, Greece.
出版信息
Mater Sociomed. 2021 Jun;33(2):119-123. doi: 10.5455/msm.2021.33.119-123.
BACKGROUND
It is a global fact that the birth weight is increasing during the years around the world and for this reason it is very important to be examined as a potential risk factor for breast cancer. According to data from World Health Organization, breast cancer is the second most frequent malignancy across the world, after lung cancer, in Europe including Greece in incidence and mortality for women between the ages 0-85 years old.
OBJECTIVE
The aim of this study was to investigate a possible association between neonatal birth weight of the women and breast cancer risk in Greek women. Although that many studies concluded that birth weight is positively related with breast cancer reinforcing the theory that breast cancer may originate in utero, some studies found no association. Moreover, the results from previous studies are inconsistent maybe due to several factors such as the study design and the number of cases.
METHODS
This study was a case-control retrospective bicentric study. The case group included 238 women with breast cancer, while the control group included 153 women without breast cancer who consulted in two breast clinics in Greece. In all women, a clinical examination and breast ultrasound were achieved. Moreover, digital bilateral mammography was performed in patients older than 40 years.
RESULTS
According to Fisher's exact analysis, there is a statistically significant relationship between the higher women's neonatal birth weight and the risk for breast cancer (p<0.001). More specifically in the group of women with breast cancer, 61% of them had more than 3500 grams birth weight, in contrast with 7.8 % in the control group. In our cohort, women who had birth weight more than 3500 grams are more likely to develop breast cancer in their life.
CONCLUSION
Our study trend to show that the increased neonatal birth weight may influence future risk of breast cancer. However, further studies with larger number of participants are needed in order to clarify the role of birth weight as a complementary risk factor of breast cancer.
背景
全球范围内，近年来出生体重呈上升趋势，因此将其作为乳腺癌潜在风险因素进行研究非常重要。根据世界卫生组织的数据，在欧洲，包括希腊，乳腺癌是0至85岁女性中发病率和死亡率仅次于肺癌的第二大常见恶性肿瘤。
目的
本研究旨在调查希腊女性新生儿出生体重与乳腺癌风险之间的可能关联。尽管许多研究得出结论，出生体重与乳腺癌呈正相关，强化了乳腺癌可能起源于子宫内的理论，但也有一些研究未发现关联。此外，先前研究的结果不一致，可能是由于多种因素，如研究设计和病例数量。
方法
本研究是一项病例对照回顾性双中心研究。病例组包括238名乳腺癌女性，对照组包括153名未患乳腺癌的女性，她们在希腊的两家乳腺诊所就诊。对所有女性进行了临床检查和乳腺超声检查。此外，对40岁以上的患者进行了数字化双侧乳腺钼靶检查。
结果
根据费舍尔精确分析，女性新生儿出生体重较高与乳腺癌风险之间存在统计学显著关系（p<0.001）。具体而言，在乳腺癌女性组中，61%的女性出生体重超过3500克，而对照组为7.8%。在我们的队列中，出生体重超过3500克的女性一生中患乳腺癌的可能性更大。
结论
我们的研究趋势表明，新生儿出生体重增加可能会影响未来患乳腺癌的风险。然而，需要更多参与者进行进一步研究，以阐明出生体重作为乳腺癌补充风险因素的作用。
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