School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, 699781, Tel Aviv, Israel.
Faculty of Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel.
Chem Commun (Camb). 2021 Sep 6;57(71):8856-8884. doi: 10.1039/d1cc02906a.
NMR has been instrumental in studies of both the structure and dynamics of molecular systems for decades, so it is not surprising that NMR has played a pivotal role in the study of host-guest complexes and supramolecular systems. In this mini-review, selected examples will be used to demonstrate the added value of using (multiparametric) NMR for studying macrocycle-based host-guest and supramolecular systems. We will restrict the discussion to synthetic host systems having a cavity that can engulf their guests thus restricting them into confined spaces. So discussion of selected examples of cavitands, cages, capsules and their complexes, aggregates and polymers as well as organic cages and porous liquids and other porous materials will be used to demonstrate the insights that have been gathered from the extracted NMR parameters when studying such systems emphasizing the information obtained from somewhat less routine NMR methods such as diffusion NMR, diffusion ordered spectroscopy (DOSY) and chemical exchange saturation transfer (CEST) and their variants. These selected examples demonstrate the impact that the results and findings from these NMR studies have had on our understanding of such systems and on the developments in various research fields.
NMR 技术在过去几十年中对于分子系统的结构和动力学研究发挥了重要作用，因此 NMR 技术在研究主体-客体络合物和超分子系统中发挥了关键作用也就不足为奇了。在这篇综述中，将选择一些实例来证明使用（多参数）NMR 研究基于大环的主体-客体和超分子系统的附加价值。我们将讨论仅限于具有可以容纳客体的空腔的合成主体系统，从而将客体限制在封闭空间中。因此，将选择实例讨论穴状配体、笼状化合物、胶囊及其复合物、聚集体和聚合物以及有机笼和多孔液体和其他多孔材料，以证明从研究这些系统时提取的 NMR 参数中收集到的见解，强调从稍不常规的 NMR 方法（如扩散 NMR、扩散有序光谱（DOSY）和化学交换饱和转移（CEST）及其变体）中获得的信息。这些选择的实例证明了这些 NMR 研究的结果和发现对我们对这些系统的理解以及各个研究领域的发展的影响。
