Department of Clinical Pharmacy, School of Pharmaceutical Sciences Universiti Sains Malaysia, Penang, Malaysia.
Respiratory Department, Hospital Palau Pinang, Penang, Malaysia.
East Mediterr Health J. 2021 Aug 26;27(8):755-763. doi: 10.26719/2021.27.8.755.
In pulmonary tuberculosis (PTB), the sputum conversion rate at 2 months is frequently used to evaluate treatment outcomes and effectiveness of a TB control programme.
The study aimed to estimate the rate of delayed sputum conversion and explore its predicting factors at the end of the intensive phase among smear-positive PTB (PTB +ve) patients.
A 3-year retrospective study was conducted in the government hospital in Pulau Pinang from 2016 to 2018. During the study, a standardized, data collection form was used to collect data from the patient record. Patients aged over 18 years were recruited. Multivariable logistic regression analysis was used to identify significant independent variables associated with delayed sputum conversion.
A total 1128 of PTB patients were recorded visiting the TB clinic, 736 (65.2%) were diagnosed as PTB +ve; of these, 606 (82.3%) PTB +ve had a record of sputum conversion at the end of the intensive phase. Age ≥ 50 years, blue-collar jobs, smoking, heavy bacillary load, relapsed and treatment interrupted were significantly (P < 0.05) associated with delayed sputum conversion. Delayed sputum conversion rate at the end of the intensive phase was 30.5%.
The rate of sputum smear conversion in the intensive phase of treatment was independently associated with high sputum smear grading at diagnosis, relapsed and treatment interrupted categories, old age and blue-collar occupations.
在肺结核（PTB）中，通常使用 2 个月时的痰转阴率来评估治疗结果和结核病控制规划的效果。
本研究旨在评估涂阳肺结核（PTB + ve）患者强化期结束时迟发性痰转化的发生率，并探讨其预测因素。
对 2016 年至 2018 年在槟城政府医院进行的为期 3 年的回顾性研究。在此期间，使用标准化数据收集表从患者病历中收集数据。纳入年龄大于 18 岁的患者。使用多变量逻辑回归分析来确定与迟发性痰转化相关的显著独立变量。
共记录了 1128 例肺结核患者到结核病诊所就诊，其中 736 例（65.2%）被诊断为 PTB + ve；其中，606 例（82.3%）PTB + ve 在强化期结束时有痰转化记录。年龄≥50 岁、蓝领工作、吸烟、细菌负荷重、复发和治疗中断与迟发性痰转化显著相关（P < 0.05）。强化期结束时迟发性痰转化率为 30.5%。
治疗强化期痰涂片转化率与诊断时高痰涂片分级、复发和治疗中断、年龄较大和蓝领职业独立相关。
