Is there an association between urine biochemical parameters on admission and the severity OF COVID-19?

AIM

To determine the importance of urinary biochemical parameters on the severity of coronavirus disease-2019 (COVID-19).

METHODS

One hundred and thirty-three patients who were diagnosed with COVID-19 were retrospectively included. Groups were formed according to the severity of their disease (moderate [n = 85], severe [n = 29] and critical = [n = 19]), and an additional control group was created from healthy individuals (n = 50). We investigated the correlation between urine biochemical parameters and the severity of the disease.

RESULTS

Erythrocyturia, proteinuria and glucosuria rates were significantly higher in patients than in the controls. In patients, the median urine specific gravity (SG) was lower (P < .001), and the median potential of hydrogen (pH) value was higher compared with the controls (P < .001). In correlation analyses, there were strong positive correlations between disease severity and age (r = 0.545, P < .001), RR (r = 0.838, P < .001) and proteinuria (r = 0.462, P < .001), while there was a strong negative correlation with SpO (r = -0.839, P = .001). On multivariate analysis, age (OR: 1.06, 95% CI 1.03-1.10, P = .035), respiratory rate ≥30 breaths/min (OR: 4.72, 95% CI 1.26-6.24, P < .0031), SpO  ≤ 93% (OR: 3.82, 95% CI 1.18-5.82, P = .001) and proteinuria (OR: 1.13, 95%CI 1.02-2.1, P = .023) were independent predictive factors for disease severity.

CONCLUSION

Proteinuria in routine urine analysis, which is one of the parameters that can be easily applied in the application, may be related to the severity of the COVID-19 disease.