Department of Medical Imaging, Clinical Medical College, Yangzhou University, No 98 West Nantong Road, 225001, Yangzhou, China.
Cancer Imaging. 2021 Sep 7;21(1):52. doi: 10.1186/s40644-021-00419-1.
Cystic renal cell carcinoma (CRCC) and cystic collecting duct carcinoma (CCDC) share similar oncogeni and some imaging findings. The aim of this study was to characterize the clinical and CT imagings features of CRCC and CCDC.
Thirty-three patients with CRCC and thirteen patients with CCDC with pathologically proven were retrospectively studied. Tumor characteristics were assessed.
On CT imaging, 33 patients(100 %) with CRCC and 13 patients(100 %) with CCDC, tumors calcifications (8 vs. 9, P < 0.0001), had a clear boundary (capsule sign, 30 vs. 2, P < 0.0001), infiltrative appearance (1 vs. 13, P < 0.0001), exogenous appearance (29 vs. 3, P < 0.0001), invaded the renal pelvis or ureter (1 vs. 10, P < 0.0001), hemorrhage (1 vs. 10, P < 0.0001), had retroperitoneal lymph node or distant metastasis (2 vs. 10, P < 0.0001), thickened enhancing internal septations (31 vs. 2, P < 0.0001), and mural soft-tissue nodules (21 vs. 1, P < 0.0001). On MR imaging,13 patients(39 %) with CRCC and 4 patients(31 %) with CCDC, all CRCCs appeared hypointense on T1-weighted images and hyperintense on T2-weighted images, however, all CCDCs appeared hypointense on T1-weighted images and hypointense on T2-weighted images(P < 0.0001). 33 patients with CRCC, they were all alive from3 years to 10 years follow-up, however, 13 patients with CCDC, of which 11 patients were able to be followed up, and 9 patients expired within 5 years of the initial diagnosis and the others are currently still alive.
Distinguishing features of CRCC and CCDC included calcifications, capsule signs, infiltrative appearance, metastasis, internal septations, mural nodules and signal on CT or MR images. These imaging features may help in differentiating the two renal tumor types.
囊性肾细胞癌（CRCC）和囊性集合管癌（CCDC）具有相似的致癌基因和一些影像学表现。本研究旨在描述 CRCC 和 CCDC 的临床和 CT 影像学特征。
回顾性分析经病理证实的 33 例 CRCC 患者和 13 例 CCDC 患者的资料。评估肿瘤特征。
在 CT 影像学上，33 例（100%）CRCC 患者和 13 例（100%）CCDC 患者的肿瘤均有钙化（8 例比 9 例，P<0.0001）、边界清晰（包膜征，30 例比 2 例，P<0.0001）、浸润性外观（1 例比 13 例，P<0.0001）、外生性外观（29 例比 3 例，P<0.0001）、侵犯肾盂或输尿管（1 例比 10 例，P<0.0001）、出血（1 例比 10 例，P<0.0001）、腹膜后淋巴结或远处转移（2 例比 10 例，P<0.0001）、增厚的增强内部分隔（31 例比 2 例，P<0.0001）和壁软组织结节（21 例比 1 例，P<0.0001）。在 MR 成像上，13 例（39%）CRCC 患者和 4 例（31%）CCDC 患者，所有 CRCC 在 T1 加权图像上呈低信号，在 T2 加权图像上呈高信号，而所有 CCDC 在 T1 加权图像上呈低信号，在 T2 加权图像上呈低信号（P<0.0001）。33 例 CRCC 患者在 3 年至 10 年的随访中均存活，而 13 例 CCDC 患者中，11 例可随访，9 例在初始诊断后 5 年内死亡，其余患者目前仍存活。
CRCC 和 CCDC 的鉴别特征包括钙化、包膜征、浸润性外观、转移、内部分隔、壁结节和 CT 或 MR 图像上的信号。这些影像学特征有助于区分两种肾肿瘤类型。
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