希腊性少数男性群体中暴露前预防措施的持续性：希腊暴露前预防研究（P4G）的结果
Pre-exposure Prophylaxis Persistence Among Greek Sexual Minority Men: Results from PrEP for Greece (P4G) Study.
作者信息
Waetjen Mweya, Papadopoulou Martha, Flores Rey, Sypsa Vana, Roussos Sotiris, Chanos Sophocles, Dedes Nikos, Liao Chuanhong, Paraskevis Dimitrios, Hatzakis Angelos, Schneider John, Psichogiou Mina
机构信息
Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
First Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
出版信息
AIDS Behav. 2022 Apr;26(4):1039-1046. doi: 10.1007/s10461-021-03459-7. Epub 2021 Sep 7.
Nearly half the new HIV infections in Greece occur in sexual minority men, yet pre-exposure prophylaxis is not currently supported in the national HIV program. We examined factors associated with PrEP persistence among Greek SMM in PrEP for Greece, the first PrEP study in Greece. Participants (n = 100) were recruited from 2016 to 2018 through respondent-driven sampling among SMM in Athens, receiving supplies for daily PrEP at interval visits over 12-months. PrEP persistence, operationalized as Total PrEP Time, was high, 74% of participants achieving perfect persistence. Higher alcohol risk scores (OR 1.27, 95% CI 1.08-1.49) and adherence to HIV testing guidelines (OR 1.23, 95% CI 1.00-1.51) were associated with persistence. Housing impermanence (OR 0.14, 95% CI 0.04-0.48) and serostatus disclosure concerns (OR 0.77, 95% CI 0.60-0.97) were associated with limited PrEP persistence. While PrEP persistence among Greek SMM is high, socioeconomic factors and societal attitudes may challenge prevention efforts.
希腊近一半的新增艾滋病病毒感染发生在性少数男性中，但目前国家艾滋病病毒防治项目并不支持暴露前预防（PrEP）。我们在希腊的首个PrEP研究“希腊PrEP项目”中，调查了与希腊性少数男性（SMM）坚持PrEP相关的因素。研究参与者（n = 100）于2016年至2018年通过雅典性少数男性中的应答驱动抽样招募，在为期12个月的定期访视中接受每日PrEP药物供应。以总PrEP时间衡量的PrEP坚持率很高，74%的参与者实现了完美坚持。较高的酒精风险评分（比值比[OR] 1.27，95%置信区间[CI] 1.08 - 1.49）和遵守艾滋病病毒检测指南（OR 1.23，95% CI 1.00 - 1.51）与坚持率相关。居住不稳定（OR 0.14，95% CI 0.04 - 0.48）和对血清学状态披露的担忧（OR 0.77，95% CI 0.60 - 0.97）与PrEP坚持受限相关。虽然希腊性少数男性的PrEP坚持率很高，但社会经济因素和社会态度可能会对预防工作构成挑战。
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