异基因造血干细胞移植后发生两例唇部癌：病例报告及文献综述
Two Lip Carcinomas following Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report and Literature Review.
作者信息
Dammak Nouha, Berrezouga Latifa, Njima Manel, Lahouel Ines, Khemiss Mehdi, Ben Khelifa Mohamed
机构信息
Medicine and Oral Surgery Department, University Clinic of Dental Medicine, Monastir, Tunisia.
Dental Medicine Department, Fattouma Bourguiba Teaching Hospital, Monastir, Tunisia.
出版信息
Int J Dent. 2021 Aug 27;2021:6662381. doi: 10.1155/2021/6662381. eCollection 2021.
BACKGROUND
Secondary solid cancers are severe complications in patients who have undergone allogeneic hematopoietic stem cell transplantation (AHSCT) for malignant and nonmalignant lymphohematopoietic diseases.
OBJECTIVE
The aim of this work was to report a case of two lip carcinomas following AHSCT and to warn doctors about the importance of regular check-ups of patients who have received HSCT. . A 57-year-old man was referred by the dermatology department for the management of exophytic budding lesions on the lower lip evolving since 5 months. The patient was in complete remission following allogeneic bone marrow transplantation for acute myeloid leukemia since five years. Clinical and histological findings confirmed the diagnosis of a squamous cell carcinoma of the two lesions.
CONCLUSION
It is of paramount importance to seek an oral squamous cell carcinoma in the presence of persistent lesions in HSCT recipients.
背景
继发性实体癌是患有恶性和非恶性淋巴造血疾病的患者接受异基因造血干细胞移植（AHSCT）后的严重并发症。
目的
本研究旨在报告1例异基因造血干细胞移植后发生两例唇癌的病例，并提醒医生对接受造血干细胞移植的患者进行定期检查的重要性。一名57岁男性因下唇外生性芽状病变5个月来皮肤科就诊。该患者5年前因急性髓系白血病接受异基因骨髓移植后处于完全缓解状态。临床和组织学检查结果证实了这两个病变为鳞状细胞癌。
结论
对于造血干细胞移植受者出现持续性病变的情况，排查口腔鳞状细胞癌至关重要。
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