Miura T, Harasawa S, Kikuchi K, Miwa T
Department of Internal Medicine, School of Medicine, Tokai University.
Tokai J Exp Clin Med. 1987 May;12(2):109-15.
A dog model was used for direct measurement of the sphincter of Oddi using endoscopy. The effects of anticholinergic agents and a selective antimuscarinic agent on the canine sphincter of Oddi motility were studied. Manometric tracing at the canine sphincter showed rhythmical phasic contractions which were not affected by respiration. The mean values of the basal motility were as follows: the peak pressure was 61.5 +/- 2.2 (m +/- SE) cmH2O, trough pressure was 2.18 +/- 1.2 cmH2O, and the frequency was 17.4 +/- 0.2 waves/min. Intravenous administration of atropine sulfate, butropium bromide, butylscopolamine bromide and also pirenzepine significantly reduced the amplitude and frequency of canine sphincter contractions. From these results, it appeared that the cholinergic autonomic nervous system might be the one of the regulators of the canine sphincter of Oddi activity.
采用犬模型通过内镜直接测量Oddi括约肌。研究了抗胆碱能药物和选择性抗毒蕈碱药物对犬Oddi括约肌运动的影响。犬括约肌的测压描记显示有节律的阶段性收缩，不受呼吸影响。基础运动的平均值如下：峰值压力为61.5±2.2（m±SE）cmH2O，谷值压力为2.18±1.2 cmH2O，频率为17.4±0.2次/分钟。静脉注射硫酸阿托品、溴化丁溴东莨菪碱、溴化丁基东莨菪碱以及哌仑西平均显著降低了犬括约肌收缩的幅度和频率。从这些结果来看，胆碱能自主神经系统可能是犬Oddi括约肌活动的调节因子之一。
