Department of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan.
Department of Veterinary Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan; Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, Tokyo, Japan.
J Comp Pathol. 2021 Aug;187:7-10. doi: 10.1016/j.jcpa.2021.06.005. Epub 2021 Jul 20.
A 12-year-old castrated male Jack Russell Terrier presented with intermittent vomiting. Abdominal ultrasonographic examination detected a thickened stomach wall with a mass measuring approximately 1.5 cm in diameter. Computed tomography revealed a solitary mass measuring approximately 2.1 cm in diameter between the submucosa and muscle layers in the greater curvature the pyloric region of the stomach, and a swelling in the hepatic lymph node. The gastric mass was composed of round neoplastic cells arranged in a diffuse pattern. The neoplastic cells had a round nucleus and a pale abundant cytoplasm. Multinucleated giant cells were often found. Hyalinized eosinophilic material, which did not stain with Congo red and had no affinity for thioflavin T, was also observed. Neoplastic cells were immunopositive for MUM1, CD79a and Ig lambda light chain but negative for CD3, CD20, BLA36, IgG and Ig kappa light chain. Stromal eosinophilic material was positive for Ig lambda light chain. The neoplasm was therefore diagnosed as a gastric plasmacytoma with non-amyloid Ig lambda light chain deposition.
一只 12 岁已去势的雄性杰克罗素梗间歇性呕吐。腹部超声检查发现胃壁增厚，直径约 1.5 厘米处有一肿块。计算机断层扫描显示胃幽门区大弯黏膜下层和肌层之间有一个直径约 2.1 厘米的单发肿块，肝淋巴结肿大。胃肿块由排列成弥漫模式的圆形肿瘤细胞组成。肿瘤细胞有一个圆形的核和一个苍白丰富的细胞质。常发现多核巨细胞。还观察到嗜酸性透明物质，刚果红染色阴性，硫代黄素 T 无亲和力。肿瘤细胞免疫阳性表达 MUM1、CD79a 和 Ig lambda 轻链，但阴性表达 CD3、CD20、BLA36、IgG 和 Ig kappa 轻链。间质嗜酸性物质阳性表达 Ig lambda 轻链。因此，诊断为胃浆细胞瘤伴非淀粉样 Ig lambda 轻链沉积。
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