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Endothelial dysfunction and its critical role in COVID-19-associated coagulopathy: Defibrotide as an endothelium-protective, targeted therapy.

作者信息

García-Bernal David, Richardson Edward, Vlodavsky Israel, Carlo-Stella Carmelo, Iacobelli Massimo, Jara Rubén, Richardson Paul G, Moraleda Jose M

机构信息

Department of Medicine Hematopoietic Transplant and Cellular Therapy Unit IMIB-Arrixaca Virgen de la Arrixaca University Hospital University of Murcia Murcia Spain.

Frank H. Netter M.D. School of Medicine Quinnipiac University North Haven Connecticut USA.

出版信息

EJHaem. 2021 Jun 22;2(3):680-681. doi: 10.1002/jha2.198. eCollection 2021 Aug.

Abstract
摘要

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本文引用的文献

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COVID-19 coagulopathy: is it disseminated intravascular coagulation?
Intern Emerg Med. 2021 Mar;16(2):309-312. doi: 10.1007/s11739-020-02601-y. Epub 2020 Dec 24.
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Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients.
EBioMedicine. 2020 Sep;59:102969. doi: 10.1016/j.ebiom.2020.102969. Epub 2020 Aug 25.
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Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.
Lancet Haematol. 2020 Aug;7(8):e575-e582. doi: 10.1016/S2352-3026(20)30216-7. Epub 2020 Jun 30.
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Defibrotide inhibits donor leucocyte-endothelial interactions and protects against acute graft-versus-host disease.
J Cell Mol Med. 2020 Jul;24(14):8031-8044. doi: 10.1111/jcmm.15434. Epub 2020 Jun 10.
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Heparanase, cell signaling, and viral infections.
Cell Mol Life Sci. 2020 Dec;77(24):5059-5077. doi: 10.1007/s00018-020-03559-y. Epub 2020 May 27.
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Endothelial cell infection and endotheliitis in COVID-19.
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Hematological findings and complications of COVID-19.
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The use of defibrotide in blood and marrow transplantation.
Blood Adv. 2018 Jun 26;2(12):1495-1509. doi: 10.1182/bloodadvances.2017008375.
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Preclinical studies in support of defibrotide for the treatment of multiple myeloma and other neoplasias.
Clin Cancer Res. 2009 Feb 15;15(4):1210-21. doi: 10.1158/1078-0432.CCR-08-1270.

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