Póder G, Kelemen J, Mezei G, Börzsönyi L
First Department of Paediatrics, Semmelweis University Medical School, Budapest, Hungary.
Acta Paediatr Hung. 1987;28(3-4):201-7.
The bronchial hyperreactivity was examined in a follow-up of 206 children having had obstructive bronchitis before two years of age. The acetylcholine challenge was done with 0.5% and 1% Pharmalgen solutions. The bronchial hyperreactivity was established over a 20% decrease of PEF and/or FEV1 values. Summarizing the results produced by 0.5% and 1% solutions a significant difference could be found in the bronchial hyperreactivity between the follow-up and control groups. Similarly the PC20 (provocative concentrations) values were suitable for differentiating the two groups. Upon physical exercise, EIB occurred in 2%. With the skin prick test (SPT) by 10 allergens 3+ or 4+ positivity was found in 17% of the children. Between the bronchial hyperreactivity and SPT positivity a significant correlation could be established.
对206名两岁前患过阻塞性支气管炎的儿童进行随访，检查其支气管高反应性。使用0.5%和1%的法玛尔金溶液进行乙酰胆碱激发试验。当呼气峰流速（PEF）和/或第一秒用力呼气容积（FEV1）值下降超过20%时，判定为支气管高反应性。综合0.5%和1%溶液产生的结果，随访组和对照组之间的支气管高反应性存在显著差异。同样，激发浓度（PC20）值也适用于区分两组。体育锻炼时，运动诱发的支气管收缩（EIB）发生率为2%。通过对10种变应原进行皮肤点刺试验（SPT），17%的儿童出现3+或4+阳性反应。支气管高反应性与SPT阳性之间存在显著相关性。
