多发性硬化症免疫学的新概念。

New concepts on immunology of Multiple Sclerosis.

机构信息

Service de Neurologie, CHU Nantes, France.

Univ Rennes, CHU Rennes, Neurology, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), F-35000 Rennes, France; Unité Mixte de Recherche (UMR) S1236, INSERM, University of Rennes, Etablissement Français du Sang, Rennes, France; Suivi Immunologique des Thérapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, Etablissement Français du Sang, Rennes, France.

出版信息

Presse Med. 2021 Jun;50(2):104072. doi: 10.1016/j.lpm.2021.104072. Epub 2021 Sep 20.

DOI:10.1016/j.lpm.2021.104072

PMID:34547375

Abstract

Multiple sclerosis (MS) is a chronic inflammatory and immune-driven demyelinating disease of the central nervous system (CNS). During the past decade, major advances have been made to understand the development of MS as well as its progressive stage. Here, we discuss some emerging concepts on immunology of MS, including the growing interest in the involvement of gut microbiota and the recent pathological concepts on the progression phase. Finally, we present some immuno-tools recently available that contribute to better understand diversity and function of the immune system.

摘要

多发性硬化症（MS）是一种中枢神经系统（CNS）的慢性炎症性和免疫驱动性脱髓鞘疾病。在过去的十年中，人们在理解 MS 的发展及其进展阶段方面取得了重大进展。在这里，我们讨论了一些关于 MS 免疫学的新观点，包括对肠道微生物群的参与越来越感兴趣，以及最近关于进展阶段的病理概念。最后，我们介绍了一些最近可用的免疫工具，这些工具有助于更好地了解免疫系统的多样性和功能。