外周血α1-酸性糖蛋白对米非司酮药物流产结局的预测价值及浓度相关性
Predictive value of peripheral blood α1-acid glycoprotein in medical abortion outcomes with mifepristone and relativity of concentration.
作者信息
Li Fuyao, Shou Yueyao, Zhu Ruru, Chen Xiue, Shi Beibei
机构信息
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
出版信息
Int J Gynaecol Obstet. 2022 Jul;158(1):201-204. doi: 10.1002/ijgo.13944. Epub 2021 Oct 13.
OBJECTIVE
To illustrate the predictive value of peripheral blood α1-acid glycoprotein (AAG) in abortion outcomes with mifepristone and the relativity of concentration.
METHODS
A total of 134 patients who met the criteria were enrolled. The AAG and mifepristone concentrations were determined, and Student's t-test was used to assess significant differences in the levels of AAG between the complete and incomplete abortion groups.
RESULTS
The decrease in AAG concentration was associated with incomplete abortion, whereas the increase in AAG concentration was related to complete abortion (P < 0.01). In addition, the concentration of AAG was correlated with the concentration of mifepristone (r = 0.7375, P < 0.001).
CONCLUSION
Our preliminary results suggest that AAG may serve as a biomarker for the prediction of incomplete abortions.
目的
阐明外周血α1-酸性糖蛋白（AAG）在米非司酮流产结局中的预测价值及浓度相关性。
方法
共纳入134例符合标准的患者。测定AAG和米非司酮浓度，采用Student's t检验评估完全流产组和不完全流产组之间AAG水平的显著差异。
结果
AAG浓度降低与不完全流产相关，而AAG浓度升高与完全流产相关（P<0.01）。此外，AAG浓度与米非司酮浓度相关（r = 0.7375，P<0.001）。
结论
我们的初步结果表明，AAG可能作为预测不完全流产的生物标志物。
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