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盐之颂歌：评“银屑病皮损中钠离子蓄积并反映疾病严重程度”一文。

Ode to Salt: Commentary on "Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity".

机构信息

Department of Dermatology, University of California San Francisco, San Francisco, California, USA; Dermatology Service, Veterans Affairs Health Care System, San Francisco, California, USA.

出版信息

J Invest Dermatol. 2022 Jan;142(1):16-17. doi: 10.1016/j.jid.2021.08.401. Epub 2021 Sep 24.

DOI:10.1016/j.jid.2021.08.401
PMID:34565562
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8740904/
Abstract

"Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity" (Maifeld et al., 2021) showed that skin sodium ion (Na) is increased in patients with a PASI > 5. Na concentration as well as its content were increased in these patients, supporting the proposed mechanism that increased Na concentrations enhance IL-17 expression from CD4 cells. These data initially were generated using a noninvasive technique, sodium (Na) magnetic resonance imaging, and then were verified using Na spectroscopy and atomic absorption spectrometry in ashed-skin biopsies in humans and also using mouse models of psoriasis. These findings suggest a novel pathologic mechanism for psoriasis development and target for treatment.

摘要

“银屑病患者皮肤钠离子蓄积且与疾病严重程度相关”（Maifeld 等，2021）表明，PASI>5 的患者皮肤钠离子（Na）增加。这些患者的 Na 浓度及其含量均增加，支持了这样一种提出的机制，即增加的 Na 浓度增强了 CD4 细胞的 IL-17 表达。这些数据最初是使用非侵入性技术——钠离子（Na）磁共振成像获得的，然后在人类的皮肤活检组织经灰化处理后使用 Na 光谱法和原子吸收光谱法以及银屑病的小鼠模型进行了验证。这些发现提示了银屑病发病的新病理机制和治疗靶点。

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Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity.
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