心脏停搏液在猪体外循环心脏手术中的应用相关性及建议
Relevance and Recommendations for the Application of Cardioplegic Solutions in Cardiopulmonary Bypass Surgery in Pigs.
作者信息
Glöckner Anna, Ossmann Susann, Ginther Andre, Kang Jagdip, Borger Michael A, Hoyer Alexandro, Dieterlen Maja-Theresa
机构信息
University Department for Cardiac Surgery, Heart Center Leipzig, HELIOS Clinic, 04289 Leipzig, Germany.
出版信息
Biomedicines. 2021 Sep 21;9(9):1279. doi: 10.3390/biomedicines9091279.
Cardioplegic solutions play a major role in cardiac surgery due to the fact that they create a silent operating field and protect the myocardium against ischemia and reperfusion injury. For studies on cardioplegic solutions, it is important to compare their effects and to have a valid platform for preclinical testing of new cardioplegic solutions and their additives. Due to the strong anatomical and physiological cardiovascular similarities between pigs and humans, porcine models are suitable for investigating the effects of cardioplegic solutions. This review provides an overview of the results of the application of cardioplegic solutions in adult or pediatric pig models over the past 25 years. The advantages, disadvantages, limitations, and refinement strategies of these models are discussed.
心脏停搏液在心脏手术中起着重要作用，因为它们能创造一个安静的手术视野，并保护心肌免受缺血和再灌注损伤。对于心脏停搏液的研究，比较它们的效果以及拥有一个用于新心脏停搏液及其添加剂临床前测试的有效平台很重要。由于猪和人类在解剖学和生理学上的心血管系统有很强的相似性，猪模型适合用于研究心脏停搏液的效果。这篇综述概述了过去25年中在成年或幼年猪模型中应用心脏停搏液的结果。讨论了这些模型的优点、缺点、局限性和改进策略。
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