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雌激素受体β（ERβ）在乳腺癌肥胖相关炎症状态下维持线粒体网络并调节侵袭性。

Estrogen Receptor Beta (ERβ) Maintains Mitochondrial Network Regulating Invasiveness in an Obesity-Related Inflammation Condition in Breast Cancer.

作者信息

Martinez-Bernabe Toni, Sastre-Serra Jorge, Ciobu Nicolae, Oliver Jordi, Pons Daniel Gabriel, Roca Pilar

机构信息

Grupo Multidisciplinar de Oncología Traslacional, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, 07122 Palma de Mallorca, Illes Balears, Spain.

Instituto de Investigación Sanitaria de las Islas Baleares (IdISBa), Hospital Universitario Son Espases, Edificio S, 07120 Palma de Mallorca, Illes Balears, Spain.

出版信息

Antioxidants (Basel). 2021 Aug 28;10(9):1371. doi: 10.3390/antiox10091371.

DOI:10.3390/antiox10091371
PMID:34573003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8466315/
Abstract

Obesity, a physiological situation where different proinflammatory cytokines and hormones are secreted, is a major risk factor for breast cancer. Mitochondrial functionality exhibits a relevant role in the tumorigenic potential of a cancer cell. In the present study, it has been examined the influence of an obesity-related inflammation ELIT treatment (17β-estradiol, leptin, IL-6, and TNFα), which aims to stimulate the hormonal conditions of a postmenopausal obese woman on the mitochondrial functionality and invasiveness of MCF7 and T47D breast cancer cell lines, which display a different ratio of both estrogen receptor isoforms, ERα and ERβ. The results showed a decrease in mitochondrial functionality, with an increase in oxidative stress and invasiveness and motility, in the MCF7 cell line (high ERα/ERβ ratio) compared to a maintained status in the T47D cell line (low ERα/ERβ ratio) after ELIT treatment. In addition, breast cancer biopsies were analyzed, showing that breast tumors of obese patients present a high positive correlation between IL-6 receptor and ERβ and have an increased expression of cytokines, antioxidant enzymes, and mitochondrial biogenesis and dynamics genes. Altogether, giving special importance to ERβ in the pathology of obese patients with breast cancer is necessary, approaching to personalized medicine.

摘要

肥胖是一种会分泌多种促炎细胞因子和激素的生理状态，是乳腺癌的主要危险因素。线粒体功能在癌细胞的致瘤潜能中发挥着重要作用。在本研究中，研究了一种与肥胖相关的炎症ELIT治疗（17β-雌二醇、瘦素、白细胞介素-6和肿瘤坏死因子α）的影响，该治疗旨在模拟绝经后肥胖女性的激素状况，对MCF7和T47D乳腺癌细胞系的线粒体功能和侵袭性进行研究，这两种细胞系中雌激素受体亚型ERα和ERβ的比例不同。结果显示，与ELIT治疗后T47D细胞系（ERα/ERβ比例低）的线粒体功能维持稳定相比，MCF7细胞系（ERα/ERβ比例高）的线粒体功能下降，氧化应激、侵袭性和运动性增加。此外，对乳腺癌活检组织进行分析，结果表明肥胖患者的乳腺肿瘤中白细胞介素-6受体与ERβ之间呈高度正相关，且细胞因子、抗氧化酶以及线粒体生物发生和动力学相关基因的表达增加。总之，在乳腺癌肥胖患者的病理研究中重视ERβ很有必要，这有助于实现个性化医疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/20f1a42070e3/antioxidants-10-01371-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/1cc48bc313ca/antioxidants-10-01371-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/9ab82fd4d147/antioxidants-10-01371-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/20f1a42070e3/antioxidants-10-01371-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/1cc48bc313ca/antioxidants-10-01371-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/58655e3a04fd/antioxidants-10-01371-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/3bee3ef684fa/antioxidants-10-01371-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/4be87ef1ee2e/antioxidants-10-01371-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/379bfd01cd70/antioxidants-10-01371-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/99e930d5bcb9/antioxidants-10-01371-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/9ab82fd4d147/antioxidants-10-01371-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eea/8466315/20f1a42070e3/antioxidants-10-01371-g008.jpg

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