Hammerman C, Strates E, Berger S, Zaia W, Aldousany A
Crit Care Med. 1986 May;14(5):462-5. doi: 10.1097/00003246-198605000-00005.
Prostaglandin (PG) levels and M-mode echocardiography were used to evaluate the severity of patent ductus arteriosus (PDA) in 19 premature infants. Mean 6-keto-PGF1 alpha levels in infants with more severe left-to-right shunting were significantly higher than those in infants with a moderate level of shunting (1335 +/- 763 vs. 504 +/- 348 pg/ml, respectively). Furthermore, there was a significant correlation between this elevation and a decrease in the left ventricular systolic time interval, suggesting that both reflect the severity of ductal shunting. Although other echocardiographic measurements of cardiovascular function generally showed some tendency to vary with 6-keto-PGF1 alpha levels, none was as closely correlated with the extent of PG elevation. Levels of PGE2 also seemed to vary with PDA severity; however, this correlation was not as significant.
采用前列腺素（PG）水平和M型超声心动图评估19例早产儿动脉导管未闭（PDA）的严重程度。左向右分流较严重的婴儿平均6-酮-前列环素F1α水平显著高于分流程度中等的婴儿（分别为1335±763与504±348 pg/ml）。此外，这种升高与左心室收缩时间间期缩短显著相关，提示二者均反映导管分流的严重程度。尽管心血管功能的其他超声心动图测量指标一般显示出随6-酮-前列环素F1α水平变化的某种趋势，但无一与PG升高程度密切相关。前列腺素E2水平似乎也随PDA严重程度而变化；然而，这种相关性不显著。
