硝吡啶作为 1,3-偶极环加成与 N-甲基亚甲胺叶立德的 2π-配体：缩吡咯烷的易得途径。
Nitropyridines as 2π-Partners in 1,3-Dipolar Cycloadditions with N-Methyl Azomethine Ylide: An Easy Access to Condensed Pyrrolines.
机构信息
N.D. Zelinsky Institute of Organic Chemistry RAS, Leninsky Prosp. 47, 119991 Moscow, Russia.
出版信息
Molecules. 2021 Sep 13;26(18):5547. doi: 10.3390/molecules26185547.
Abstract
1,3-Dipolar cycloaddition reactions of 2-substituted 5--3-nitropyridines and isomeric 3--5-nitropyridines with N-methyl azomethine ylide were studied. The effect of the substituent at positions 2 and 5 of the pyridine ring on the possibility of the [3+2]-cycloaddition process was revealed. A number of new derivatives of pyrroline and pyrrolidine condensed with a pyridine ring were synthesized.
摘要
2-取代-5-（3-硝基吡啶）和异-3-（5-硝基吡啶）与 N-甲基氮杂环丙烷亚基的 1,3-偶极环加成反应进行了研究。揭示了吡啶环上 2 位和 5 位取代基对[3+2]-环加成过程可能性的影响。合成了一系列与吡啶环稠合的吡咯啉和吡咯烷的新衍生物。
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