Strauss R G
Am J Clin Nutr. 1978 Apr;31(4):660-6. doi: 10.1093/ajcn/31.4.660.
Many physicians believe that patients with iron deficiency have an increased susceptibility to infections. Data in the literature, however, are contradictory, and in many instances the reports are vulnerable to critical review. Literature available through 1976 was analyzed in an attempt to define possible relationships between infections, immune function, and states of iron imbalance, both iron deficiency and overload. Critical points that must be considered for an accurate interpretation were emphasized. It seems clear that the inflammatory response, when assessed by skin reactivity, is diminished in iron deficiency. The precise molecular defect remains undefined, but the abnormality is detected by several assays measuring cell-mediated immunity. Normal function is usually restored following iron repletion.
许多医生认为缺铁患者更容易感染。然而，文献中的数据相互矛盾，而且在很多情况下这些报告经不起严格审查。对1976年以前的文献进行了分析，试图确定感染、免疫功能与铁失衡状态（缺铁和铁过载）之间可能存在的关系。强调了准确解释时必须考虑的关键点。显然，通过皮肤反应性评估的炎症反应在缺铁时会减弱。确切的分子缺陷尚不清楚，但通过几种测量细胞介导免疫的检测方法可检测到这种异常。补铁后通常可恢复正常功能。
