黄体生成素（LH）和促黄体生成素释放激素（LHRH）对妊娠晚期胎兔睾丸体内睾酮生成的影响。

Effect of luteinizing hormone (LH) and LH-releasing hormone (LHRH) on testosterone production in vivo, in fetal rabbit testis in late gestation.

作者信息

Veyssière G, Berger M, Jean-Faucher C, de Turckheim M, Jean C

出版信息

Biol Neonate. 1977;32(5-6):327-30. doi: 10.1159/000241036.

Abstract

Plasma and tesicular testosterone were measured by radioimmunoassay in the 29-day-old rabbit fetus receiving an injection of saline solution, LH or LHRH. 30 min following the injection of 5 microgram LH into the umbilical vein, testosterone levels were significantly increased by 287% in the plasma and 293% in the testis, compared with controls receiving saline solution. The injection of 2 microgram of LHRH under the same conditions significantly increased testicular testosterone by 256% and plasma testosterone by 746%. The results show that the fetal rabbit testis, at the end of gestation, is capable of responding to LH stimulation. The hypophysio-testicular axis is apparently functional at this stage of gestation, as shown by the response to LHRH.

摘要

通过放射免疫分析法测定了接受盐水溶液、促黄体生成素（LH）或促性腺激素释放激素（LHRH）注射的29日龄兔胎儿的血浆和睾丸睾酮水平。向脐静脉注射5微克LH后30分钟，与接受盐水溶液的对照组相比，血浆睾酮水平显著升高287%，睾丸睾酮水平显著升高293%。在相同条件下注射2微克LHRH，睾丸睾酮显著升高256%，血浆睾酮显著升高746%。结果表明，妊娠末期的兔胎儿睾丸能够对LH刺激作出反应。如对LHRH的反应所示，在妊娠这个阶段，垂体-睾丸轴显然是有功能的。