Department of Biomedical Engineering, University of California at Davis, Davis, CA 95616, United States of America.
Phys Med Biol. 2021 Oct 19;66(21). doi: 10.1088/1361-6560/ac2c9c.
Dual-ended readout depth-encoding detectors based on bismuth germanate (BGO) scintillation crystal arrays are good candidates for high-sensitivity small animal positron emission tomography used for very-low-dose imaging. In this paper, the performance of three dual-ended readout detectors based on 15 × 15 BGO arrays with three different reflector arrangements and 8 × 8 silicon photomultiplier arrays were evaluated and compared.
The three BGO arrays, denoted wo-ILG (without internal light guide), wp-ILG (with partial internal light guide), and wf-ILG (with full internal light guide), share a pitch size of 1.6 mm and thickness of 20 mm. Toray E60 with a thickness of 50m was used as inter-crystal reflector. All reflector lengths in the wo-ILG and wf-ILG BGO arrays were 20 and 18 mm, respectively; the reflectors in the wp-ILG BGO array were 18 mm at the central region of the array and 20 mm at the edge. By using 18 mm reflectors, part of the crystals in the wp-ILG and wf-ILG BGO arrays worked as internal light guides.
The results showed that the detector based on the wo-ILG BGO array provided the best flood histogram. The energy, timing and DOI resolutions of the three detectors were similar. The energy resolutions full width at half maximum (FWHM value) based on the wo-ILG, wp-ILG and wf-ILG BGO arrays were 27.2 ± 3.9%, 28.7 ± 4.6%, and 29.5 ± 4.7%, respectively. The timing resolutions (FWHM value) were 4.7 ± 0.5 ns, 4.9 ± 0.5 ns, and 5.0 ± 0.6 ns, respectively. The DOI resolution (FWHM value) were 3.0 ± 0.2 mm, 2.9 ± 0.2 mm, and 3.0 ± 0.2 mm, respectively. Over all, the wo-ILG detector provided the best performance.
基于锗酸铋(BGO)闪烁晶体阵列的双端读出深度编码探测器是用于极低剂量成像的高灵敏度小动物正电子发射断层扫描的良好候选者。在本文中,评估并比较了三种基于具有三种不同反射器布置的 15×15 BGO 阵列和 8×8 硅光电倍增管阵列的双端读出探测器的性能。
三个 BGO 阵列分别标记为 wo-ILG(无内部导光管)、wp-ILG(具有部分内部导光管)和 wf-ILG(具有完全内部导光管),它们的节距大小为 1.6 毫米,厚度为 20 毫米。厚度为 50m 的东丽 E60 用作晶体间反射器。wo-ILG 和 wf-ILG BGO 阵列中的所有反射器长度均为 20 毫米,而 wo-ILG BGO 阵列中的反射器长度为 18 毫米;wp-ILG BGO 阵列的中央区域的反射器长度为 18 毫米,边缘的反射器长度为 20 毫米。通过使用 18 毫米的反射器,wp-ILG 和 wf-ILG BGO 阵列中的部分晶体充当内部导光管。
结果表明,基于 wo-ILG BGO 阵列的探测器提供了最佳的洪水直方图。三个探测器的能量、时间和 DOI 分辨率相似。基于 wo-ILG、wp-ILG 和 wf-ILG BGO 阵列的能量分辨率半高全宽(FWHM 值)分别为 27.2±3.9%、28.7±4.6%和 29.5±4.7%。时间分辨率(FWHM 值)分别为 4.7±0.5 ns、4.9±0.5 ns 和 5.0±0.6 ns。DOI 分辨率(FWHM 值)分别为 3.0±0.2 mm、2.9±0.2 mm 和 3.0±0.2 mm。总的来说,wo-ILG 探测器提供了最佳性能。