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关节镜下一步法基质辅助骨髓刺激治疗距骨骨软骨缺损。

Arthroscopic one-step matrix-assisted bone marrow stimulation for the treatment of osteochondral defects of the talus.

机构信息

Department for Orthopaedic Sports Medicine, Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany.

Department for Trauma Surgery, Klinikum Wels-Grieskirchen, Grieskirchner Straße 42, 4600, Wels, Austria.

出版信息

Oper Orthop Traumatol. 2022 Aug;34(4):295-302. doi: 10.1007/s00064-021-00737-4. Epub 2021 Oct 5.

Abstract

OBJECTIVE

All arthroscopic one-step treatment of osteochondral defects of the talus with matrix-assisted bone marrow stimulation with a cell-free hyaluronic acid 3D matrix.

INDICATIONS

Symptomatic osteochondral defects of the talus (1-2 cm, ICRS III-IV).

CONTRAINDICATIONS

Large non-shouldered osteochondral defects (2 cm) of the talus, arthritis, kissing lesions of the distal tibia, metabolic arthropathies, non-reconstructable defects, hindfoot malalignment, chronic inflammatory systemic disorders.

SURGICAL TECHNIQUE

Arthroscopic examination of the ankle joint and visualization of the osteochondral defect of the talus to confirm the indication via standard portals. First, debridement of the osteochondral defect with arthroscopic curette or shaver, removal of loose fragments, resection of the sclerotic bone via shaver and measurement of the defect size. Second, multiple perforation of the subchondral plate to recruit mesenchymal stem cells from the underlying bone marrow by an microfracturing awl to stimulate the differentiation of fibrocartilaginous repair tissue in the defect zone. Then, the cell-free hyaluronic acid 3D matrix is placed into the defect via arthroscopic forceps and modulated by a probe to avoid detachment of the matrix by ankle joint movement.

POSTOPERATIVE MANAGEMENT

Postoperative management includes movement restrictions for pro- and supination but free passive dorsal extension and plantar flexion. No weight-bearing is allowed for 6 weeks.

RESULTS

Twenty-three patients (male: 11/women: 12) with a mean age of 33 years (range: 18-56) and a minimum follow-up of 24 months were included in this retrospective two-center study. The mean values for Foot and Ankle Outcome Score (FAOS) were 79 (range 33-93), for Tegner score 3 (range: 1-5) and the Visual analog scale (VAS) pain 1 (range: 0-3) and VAS function 2 (range: 0-5). At follow-up, MRI was available in 17 of 23 patients. MRI results showed a mean Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score of 81 (range: 65-90). Complications were not observed during the follow-up period.

摘要

目的

采用无细胞透明质酸 3D 基质辅助骨髓刺激对距骨骨软骨缺损进行一步法关节镜治疗。

适应证

距骨骨软骨缺损有症状(1-2cm,ICRS III-IV)。

禁忌证

距骨大非肩袖骨软骨缺损(2cm)、关节炎、胫骨远端吻接病变、代谢性关节病、不可重建缺损、后足对线不良、慢性炎症性全身疾病。

手术技术

踝关节关节镜检查和距骨骨软骨缺损可视化,通过标准入路确认适应证。首先,用关节镜刮匙或刨削器清除骨软骨缺损,去除游离碎片,用刨削器切除硬化骨,并测量缺损大小。其次,通过微骨折锥对软骨下骨板进行多次穿孔,从下方骨髓募集间充质干细胞,以刺激缺损区纤维软骨修复组织的分化。然后,通过关节镜夹具将无细胞透明质酸 3D 基质放入缺损部位,并通过探针进行调节,以避免基质因踝关节运动而脱落。

术后管理

术后管理包括前旋和后旋受限,但允许自由被动背屈和跖屈。6 周内不允许负重。

结果

本回顾性双中心研究共纳入 23 例患者(男 11 例/女 12 例),平均年龄 33 岁(范围 18-56 岁),随访时间至少 24 个月。足部和踝关节结局评分(FAOS)的平均数值为 79(范围 33-93),Tegner 评分为 3(范围:1-5),视觉模拟评分(VAS)疼痛评分为 1(范围:0-3),VAS 功能评分为 2(范围:0-5)。随访时,23 例患者中有 17 例可获得 MRI 结果。MRI 结果显示平均磁共振软骨修复组织观察评分(MOCART)为 81(范围:65-90)。随访期间未观察到并发症。

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