Gonzalez-Latapi Paulina, Sousa Mario, Lang Anthony E
The Edmond J. Safra Program for Parkinson Disease, Movement Disorder Clinic Toronto Western Hospital, University Health Network Toronto Ontario Canada.
Division of Neurology, Department of Medicine University of Toronto Toronto Ontario Canada.
Mov Disord Clin Pract. 2021 Jul 29;8(7):997-1011. doi: 10.1002/mdc3.13308. eCollection 2021 Oct.
A variety of movement disorders can be associated with hypogonadism. Identification of this association may aid in guiding workup and reaching an accurate diagnosis. We conducted a comprehensive and structured search to identify the most common movement disorders associated with hypogonadism. Only Case Reports and Case Series articles were included. Ataxia was the most common movement disorder associated with hypogonadism, including entities such as Gordon-Holmes syndrome, Boucher-Neuhäuser, Marinesco-Sjögren and Perrault syndrome. Tremor was also commonly described, particularly with aneuploidies such as Klinefelter syndrome and Jacob's syndrome. Other rare conditions including mitochondrial disorders and Woodhouse-Sakati syndrome are associated with dystonia and parkinsonism and either hypo or hypergonadotropic hypogonadism. We also highlight those entities where a combination of movement disorders is present. Hypogonadism may be more commonly associated with movement disorders than previously appreciated. It is important for the clinician to be aware of this association, as well as accompanying symptoms in order to reach a precise diagnosis.
多种运动障碍可能与性腺功能减退有关。识别这种关联可能有助于指导检查并做出准确诊断。我们进行了全面且结构化的检索，以确定与性腺功能减退相关的最常见运动障碍。仅纳入了病例报告和病例系列文章。共济失调是与性腺功能减退相关的最常见运动障碍，包括戈登 - 霍姆斯综合征、布歇 - 诺伊豪泽综合征、马里内斯科 - 舍格伦综合征和佩罗特综合征等。震颤也常被描述，尤其是与克兰费尔特综合征和雅各布综合征等非整倍体相关。其他罕见病症，包括线粒体疾病和伍德豪斯 - 萨卡蒂综合征，与肌张力障碍和帕金森症以及低促性腺激素或高促性腺激素性性腺功能减退有关。我们还强调了那些存在多种运动障碍组合的病症。性腺功能减退可能比之前认为的更常与运动障碍相关。临床医生了解这种关联以及伴随症状对于做出准确诊断很重要。
