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COVID-19 中的皮质类固醇:值得使用吗?

Corticosteroids for COVID-19: worth it or not?

机构信息

Biotechnology Program, Department of Mathematics and Natural Sciences, Brac University, Dhaka, Bangladesh.

Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh.

出版信息

Mol Biol Rep. 2022 Jan;49(1):567-576. doi: 10.1007/s11033-021-06793-0. Epub 2021 Oct 13.

Abstract

Pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced COVID-19 implied the presence of excessive proinflammatory cytokines and chemokines in patients causing significant morbidity and mortality. To diminish systemic hyper inflammation, a few physicians and researchers have utilized corticosteroids. Corticosteroid implementation has increased after the publication of interim guidelines regarding corticosteroid use in COVID-19 patients by WHO, despite the remaining controversies regarding long-term side effects and disease progression capability of corticosteroids. In different studies, the implementation of corticosteroids on COVID-19 patients revealed controversial results, which require further intensive research. This review will present the current outcomes and possibilities of using corticosteroids to treat COVID-19 patients.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)引起的 COVID-19 的发病机制表明,患者体内存在大量促炎细胞因子和趋化因子,导致发病率和死亡率显著升高。为了减轻全身炎症反应,一些医生和研究人员已经使用了皮质类固醇。尽管皮质类固醇在 COVID-19 患者中的使用的临时指南发表后,仍存在关于皮质类固醇的长期副作用和疾病进展能力的争议,但在世卫组织发布了关于 COVID-19 患者使用皮质类固醇的临时指南后,皮质类固醇的使用有所增加。在不同的研究中,皮质类固醇在 COVID-19 患者中的应用结果存在争议,需要进一步深入研究。这篇综述将介绍目前使用皮质类固醇治疗 COVID-19 患者的结果和可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/8511618/60cb8d057fcb/11033_2021_6793_Fig1_HTML.jpg

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