EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, Australia.
EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, Australia; School of Pharmacy, University of Queensland, Brisbane, Australia; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark.
Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119159. doi: 10.1016/j.bbamcr.2021.119159. Epub 2021 Oct 13.
Nearly all mammals rely on lactation to support their young and to ensure the continued survival of their species. Despite its importance, relatively little is known about how milk is produced and how it is ejected from the lumen of mammary alveoli and ducts. This review focuses on the latter. We discuss how a relatively small number of basal cells, wrapping around each alveolar unit, contract to forcibly expel milk from the alveolar lumen. We consider how individual basal cells coordinate their activity, the fate of these cells at the end of lactation and avenues for future deliberation and exploration.
几乎所有的哺乳动物都依赖于泌乳来哺育幼仔，并确保其物种的持续生存。尽管它很重要，但人们对乳汁的产生以及如何从乳腺腺泡和导管的管腔中排出乳汁知之甚少。本综述重点讨论后者。我们讨论了围绕每个腺泡单位的相对少数的基底细胞如何收缩，从而从腺泡腔中强制排出乳汁。我们考虑了单个基底细胞如何协调它们的活动，这些细胞在哺乳期结束时的命运，以及未来审议和探索的途径。
