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作者信息

Rexer Thomas, Son Tuan Hoang, Ruhnau Johannes, Reichl Udo

机构信息

Abteilung Bioprozesstechnik (BPT), Max-Planck-Institut für Dynamik komplexer technischer Systeme, Sandtorstraße 1, D-39106 Magdeburg, Deutschland.

出版信息

Biospektrum (Heidelb). 2021;27(6):657-659. doi: 10.1007/s12268-021-1659-4. Epub 2021 Oct 9.

DOI:10.1007/s12268-021-1659-4
PMID:34658539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8501375/
Abstract

The field of synthetic glycobiotechnology encompasses the synthesis and modification of free carbohydrates and carbohydrates linked to biomolecules. Our group develops bio-catalytic processes for the synthesis of carbohydrate building blocks, so-called sugar nucleotides, and cell-free multi-enzyme cascades to tailor carbohydrates linked to proteins. The technology can eventually help to advance our understanding of the roles of specific carbohydrates in nutrition and medicine and contribute to human health and well-being.

摘要

合成糖生物技术领域涵盖游离碳水化合物以及与生物分子相连的碳水化合物的合成与修饰。我们团队开发了生物催化方法来合成碳水化合物构建单元，即所谓的糖核苷酸，以及无细胞多酶级联反应来定制与蛋白质相连的碳水化合物。这项技术最终有助于推动我们对特定碳水化合物在营养和医学中作用的理解，并为人类健康和福祉做出贡献。

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