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FGF14-AS2通过与miR-320a/E2F1轴形成反馈环来加速胶质瘤的肿瘤发生。

FGF14-AS2 accelerates tumorigenesis in glioma by forming a feedback loop with miR-320a/E2F1 axis.

作者信息

Zhang Peng, Gu Xueping, Zhang Na, Liu Liang, Dong Xuchen, Li Haoran, Cheng Shan, Li Suwen, Yuan Jiaqi, Li Yongdong, Dong Jun

机构信息

Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China.

Rugao Hospital Affiliated to Nantong University, Nantong 226500, Jiangsu, China.

出版信息

J Cancer. 2021 Sep 3;12(21):6429-6438. doi: 10.7150/jca.62120. eCollection 2021.

DOI:10.7150/jca.62120
PMID:34659533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8489148/
Abstract

Glioma is the most common primary tumour in the central nervous system in adults, and at present, there is no effective treatment to cure this malignancy. Long noncoding RNAs (lncRNAs) are closely related to tumour progression and have attracted increasing attention in tumour research. However, the role of lncRNA FGF14-AS2 in glioma tumorigenesis has not been determined. In the present study, we found that FGF14-AS2 expression was significantly elevated in glioma tissues and was associated with poor survival in glioma patients. Silencing FGF14-AS2 inhibited the proliferation, migration and invasion ability of glioma cells. assay showed that silencing FGF14-AS2 led to inhibition of tumour growth. In addition, FGF14-AS2 was observed to promote glioma progression via the miR-320a/E2F1 axis. Moreover, E2F1 could bind to the promoter region of FGF14-AS2, thereby enhancing FGF14-AS2 expression. In conclusion, FGF14-AS2 could accelerate tumorigenesis of glioma by forming a feedback loop with the miR-320a/E2F1 axis which suggested that FGF14-AS2 could serve as a therapeutic target for glioma.

摘要

胶质瘤是成人中枢神经系统中最常见的原发性肿瘤，目前尚无有效的治疗方法来治愈这种恶性肿瘤。长链非编码RNA（lncRNAs）与肿瘤进展密切相关，在肿瘤研究中受到越来越多的关注。然而，lncRNA FGF14-AS2在胶质瘤发生中的作用尚未确定。在本研究中，我们发现FGF14-AS2在胶质瘤组织中的表达显著升高，并且与胶质瘤患者的不良生存相关。沉默FGF14-AS2可抑制胶质瘤细胞的增殖、迁移和侵袭能力。实验表明，沉默FGF14-AS2可导致肿瘤生长受到抑制。此外，观察到FGF14-AS2通过miR-320a/E2F1轴促进胶质瘤进展。而且，E2F1可与FGF14-AS2的启动子区域结合，从而增强FGF14-AS2的表达。总之，FGF14-AS2可通过与miR-320a/E2F1轴形成反馈环来加速胶质瘤的发生，这表明FGF14-AS2可作为胶质瘤的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f9/8489148/bd85c008d1b7/jcav12p6429g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f9/8489148/bd85c008d1b7/jcav12p6429g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f9/8489148/d342b963d601/jcav12p6429g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62f9/8489148/bd85c008d1b7/jcav12p6429g007.jpg

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