研究甘露糖结合凝集素 2 的炎症相关基因多态性与精神分裂症和双相情感障碍的关系。
Investigation of inflammation related gene polymorphism of the mannose-binding lectin 2 in schizophrenia and bipolar disorder.
机构信息
From the Department of Psychiatry (Aytac), Basaksehir Cam and Sakura City Hospital, from the Department of Psychiatry (Yazar), the Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery; from the Department of Medical Biology (Erol, Pehlivan), Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
出版信息
Neurosciences (Riyadh). 2021 Oct;26(4):346-356. doi: 10.17712/nsj.2021.4.20200050.
OBJECTIVES
To investigate the association between mannose-binding lectin 2 codon 54 polymorphism and clinical features of patients diagnosed with schizophrenia (SCZ) or bipolar disorder (BD).
METHODS
One hundred and eighteen patients with SCZ, 100 patients with BD, and 100 healthy volunteers were included in the case-control study. The patients consecutively admitted to the outpatient clinic in December 2017-May 2018 and were evaluated with some scales for clinical parameters. Polymerase chain reaction and RFLP were used to determine polymorphism in DNA material.
RESULTS
The gene polymorphism distributions in SCZ or BD patients were significantly different from the control group. The heterozygous genotype percentages were significantly higher in the control group than in the SCZ or BD patients (OR: 0.450; 95% Cl: 0.243-0.830; =0.010; OR: 0.532; 95%Cl: 0.284-0.995; =0.047, respectively), and there were statistically significant differences in the MBL2 polymorphism distributions between treatment-responsive SCZ or BD patients and treatment-resistant patients diagnosed with SCZ or BD. The heterozygous genotype percentages were also significantly higher in the treatment-responsive group than in the treatment-resistant group in SCZ or BD patients (OR: 7.857; 95% Cl: 1.006-61.363; =0.023; OR: 8.782; 95% Cl: 1.114-69.197; =0.016, respectively).
CONCLUSION
The presence of a heterozygous genotype seems to be favorable both in terms of the absence of SCZ and BD in the healthy population and treatment response for Turkish patients.
目的
探讨甘露聚糖结合凝集素 2 密码子 54 多态性与诊断为精神分裂症（SCZ）或双相障碍（BD）患者临床特征的关系。
方法
本病例对照研究纳入了 2017 年 12 月至 2018 年 5 月连续就诊于门诊的 118 例 SCZ 患者、100 例 BD 患者和 100 例健康志愿者。对患者进行了一些临床参数的量表评估。聚合酶链反应和 RFLP 用于确定 DNA 材料中的多态性。
结果
SCZ 或 BD 患者的基因多态性分布与对照组有显著差异。对照组杂合基因型百分比明显高于 SCZ 或 BD 患者（OR：0.450；95%Cl：0.243-0.830；=0.010；OR：0.532；95%Cl：0.284-0.995；=0.047），且 SCZ 或 BD 治疗反应患者与治疗抵抗患者之间 MBL2 多态性分布存在统计学差异。在 SCZ 或 BD 患者中，治疗反应组的杂合基因型百分比也明显高于治疗抵抗组（OR：7.857；95%Cl：1.006-61.363；=0.023；OR：8.782；95%Cl：1.114-69.197；=0.016）。
结论
在健康人群中，杂合基因型的存在似乎既不利于 SCZ 和 BD 的发生，也不利于土耳其患者的治疗反应。
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