骨髓增生异常综合征和髓系白血病中α:非α珠蛋白链合成比率增加。
Increased alpha:non-alpha globin chain synthesis ratios in myelodysplastic syndromes and myeloid leukaemia.
作者信息
Peters R E, May A, Jacobs A
出版信息
J Clin Pathol. 1986 Nov;39(11):1233-5. doi: 10.1136/jcp.39.11.1233.
Abstract
Globin chain synthesis ratios (alpha:beta + gamma) in leucocyte free reticulocytes from six of 11 patients with various myelodysplastic syndromes were high, ranging from 1.28 to 2.43. High ratios were also found for reticulocytes from two of four patients with acute myeloblastic leukaemia. Of the eight cases in which high ratios were found, seven were in patients who were either undergoing leukaemic transformation or who had already transformed. The reason for these findings is not known, but an understanding of the mechanism may give us further insight into the process of leukaemic transformation.
摘要
11例不同类型骨髓增生异常综合征患者中，6例患者无白细胞网织红细胞的珠蛋白链合成比率（α:β + γ）较高，范围为1.28至2.43。4例急性髓细胞白血病患者中，2例患者的网织红细胞也有较高比率。在发现有高比率的8例病例中，7例患者正处于白血病转化过程中或已经发生转化。这些发现的原因尚不清楚，但对其机制的了解可能会让我们对白血病转化过程有更深入的认识。
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