Prevalence of protective haplotypes of the gene for statin transport in Mexican populations.

To evaluate the genetic distribution of the and variants in the gene in Mexican Mestizo (admixed) and Native American groups. We recruited 360 volunteers who were qPCR-genotyped with TaqMan probes. Allele and genotype frequencies are reported. Among the expected - haplotypes, T-A (42.35-58.47%) was the most prevalent which relates to the normal activity of the OATP1B1 transporter. This was followed by the T-G haplotype associated with further statin transport and cholesterol reduction (32.49-43.76%). Based on these gene variants, we confirmed that a minimum fraction of the Mexican study populations would be at risk from decreasing simvastatin transport and the development of statin-induced myopathy.