SUMO 蛋白修饰肿瘤干细胞。
SUMO wrestling cancer stem cells.
机构信息
Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.
出版信息
Cell Chem Biol. 2021 Oct 21;28(10):1390-1392. doi: 10.1016/j.chembiol.2021.10.001.
Sumoylation is a reversible post-translational modification implicated in cancer. In this issue of Cell Chemical Biology, Benoit et al. describe an inhibitor of sumoylation that results in anti-proliferative effects in cancer stem cell models via the sumoylation enzyme SAE2.
SUMOylation 是一种与癌症相关的可逆翻译后修饰。在本期《细胞化学生物学》中，Benoit 等人描述了一种 SUMOylation 抑制剂，它通过 SUMOylation 酶 SAE2 导致癌症干细胞模型中的抗增殖作用。
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