Walker R J, Bailey R R, Swainson C P, Lynn K L
N Z Med J. 1986 Nov 26;99(814):894-6.
Over a 13-year period 42 patients (35 women) with systemic lupus erythematosus and renal disease had a renal biopsy. Renal involvement as the first and only manifestation of systemic lupus erythematosus was common in men. The commonest reason for renal biopsy (23/42) was the finding of proteinuria with or without haematuria. One-half of all patients had diffuse proliferative glomerulonephritis. Twenty-seven patients were treated with both prednisone and azathioprine and 10 with prednisone alone at some stage during follow-up. The renal biopsy findings were useful in assessing the severity of renal involvement and prognosis. A five-year renal survival of 72% was observed. Diffuse proliferative glomerulonephritis with renal insufficiency was associated with a poor prognosis. Those patients who were established on the dialysis/transplant programme became symptom free on no treatment.
在13年期间，42例（35例女性）患有系统性红斑狼疮和肾脏疾病的患者接受了肾活检。肾脏受累作为系统性红斑狼疮的首发且唯一表现，在男性中很常见。肾活检最常见的原因（23/42）是发现蛋白尿伴或不伴血尿。所有患者中有一半患有弥漫性增殖性肾小球肾炎。27例患者在随访的某个阶段接受了泼尼松和硫唑嘌呤联合治疗，10例仅接受了泼尼松治疗。肾活检结果有助于评估肾脏受累的严重程度和预后。观察到5年肾脏生存率为72%。伴有肾功能不全的弥漫性增殖性肾小球肾炎预后较差。那些进入透析/移植项目的患者在未接受治疗的情况下症状消失。
