顺铂对67Ga-柠檬酸盐蛋白结合及药代动力学的影响。

Effect of cis-platinum on the protein binding and pharmacokinetics of 67Ga-citrate.

作者信息

Sykes T R, Noujaim A A, Stephens-Newsham L G, NG P K, Lentle B C, Turner A R

出版信息

Int J Rad Appl Instrum B. 1986;13(5):501-4. doi: 10.1016/0883-2897(86)90127-3.

Abstract

Cis-platinum, a widely used chemotherapeutic drug, and K2PtCl4, a related complex, were found to inhibit the in vitro protein binding of 67Ga to human transferrin in isolated solution but not to whole serum. Cis-platinum treatment of rabbits resulted in enhanced protein binding and delayed blood clearance of subsequently injected 67Ga-citrate. These effects are related to the toxicity of the drug in vivo.

摘要

顺铂是一种广泛使用的化疗药物，与之相关的配合物四氯合铂酸钾（K2PtCl4）在离体溶液中能抑制67Ga与人类转铁蛋白的体外蛋白质结合，但在全血清中却无此作用。用顺铂对兔子进行治疗后，随后注射的67Ga柠檬酸盐的蛋白质结合增强，血液清除延迟。这些效应与该药物在体内的毒性有关。